SynthesisJournal of clinical gastroenterology2013
The association between metabolic syndrome and colorectal neoplasm: systemic review and meta-analysis.
Synthesis in Journal of clinical gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Metabolic Syndrome and Obesity-related cancer Risk and Survival: An Umbrella Review of Systematic Reviews With Meta-analysis of Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies.Scientific reports · 2019Pooled it
- The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis.Public health nutrition · 2015Pooled it
- Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis.Endocrine · 2013Pooled it
- The feasibility of a telephone-based weight loss intervention in rural Ohio: A pilot study.PloS one · 2023Trial
- Visceral Fat Thickness, Serum Adiponectin, and Metabolic Syndrome in Patients with Colorectal Adenomas.Journal of personalized medicine · 2024Article
- CT-determined low skeletal muscle index predicts poor prognosis in patients with colorectal cancer.Cancer medicine · 2024Article
- Article
- The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer.Frontiers in oncology · 2023Article
- Diabetes mellitus in relation to colorectal tumor molecular subtypes: A pooled analysis of more than 9000 cases.International journal of cancer · 2022Article
- Obesity, metabolic syndrome, and cancer: pathophysiological and therapeutic associations.Endocrine · 2021Review
- Type 2 diabetes mellitus increases liver transplant-free mortality in patients with cirrhosis: A systematic review and meta-analysis.World journal of clinical cases · 2021Article
- Metabolic syndrome, metabolic comorbid conditions and risk of early-onset colorectal cancer.Gut · 2021Article
- Clinical profile and outcome of patients with chronic inflammatory arthritis and metabolic syndrome.Internal and emergency medicine · 2021Article
- Low Serum Uric Acid Predicts Risk of a Composite Disease Endpoint.Medicina (Kaunas, Lithuania) · 2021Article
- Does Nonalcoholic Fatty Liver Disease Increase the Risk for Extrahepatic Malignancies?Clinical liver disease · 2021Review
- Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women.BMC medicine · 2021Article
- Metabolic syndrome and esophageal cancer risk: a systematic review and meta‑analysis.Diabetology & metabolic syndrome · 2021Review
- Multifactorial causation of early onset colorectal cancer.Journal of Cancer · 2021Article
- Metabolic associated fatty liver disease: Addressing a new era in liver transplantation.World journal of hepatology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere has been constant speculation about the association between metabolic syndrome (MetS) and colorectal neoplasia (CN); however, the published results are conflicting. The aims of this study are to conduct a systematic search, and assess the literature to determine the available evidence on the association between these two conditions.
methodsMeta-analysis was conducted based on relevant studies identified through a systematic literature review from PubMed, OvidSP, and Cochrane database during January 1980 to July 2011. A combined analysis was performed, followed by a subgroup analyses stratified by the study design, type of colorectal lesions, and sex. Publication bias was assessed using the Begg and Egger tests and visual inspection of funnel plot.
resultsEighteen studies were included in the final analysis. Overall, MetS was associated with 34% increase in the risk of CN [summary relative risk (RR), 1.34; 95% confidence interval (CI), 1.24-1.44]. The association between MetS and CN was found to be statistically significant in separate analysis for both case-control studies (summary RR, 1.58; 95% CI, 1.44-1.73) and cohort studies (summary RR, 1.21; 95% CI, 1.13-1.29). The association remained significant when analyses were restricted by type of colorectal lesions (colorectal cancer: RR, 1.30; 95% CI, 1.18-1.43; colorectal adenoma: RR, 1.37; 95% CI, 1.26-1.49). Further subgroup analysis by sex showed significant association between MetS and CN in both male and female population.
conclusionsOur meta-analysis showed significant association between presence of MetS and CN. These results may help in identifying high-risk individuals at early stage, who might benefit from targeted colorectal cancer screening intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.