Evidence map›Paper›PMID 23089849›Full record

ArticleVirus research2013

The fusion loops and membrane proximal region of Epstein-Barr virus glycoprotein B (gB) can function in the context of herpes simplex virus 1 gB when substituted individually but not in combination.

Anna Zago, Sarah A Connolly, Patricia G Spear, Richard Longnecker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna ZagoDepartment of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA.
Sarah A Connolly
Patricia G Spear
Richard Longnecker

Funding

Structural and Functional Studies of gp42 and HLA Class II in EBV EntryR01AI076183 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JARDETZKY, THEODORE S, LONGNECKER, RICHARD M · 2008 to 2017
$4.6M
HERPESVIRUS GENE EXPRESSION IN TRANSFORMED CELLSR01CA021776 · NCI · UNIVERSITY OF CHICAGO · PI LONGNECKER, RICHARD M · 1985 to 2017
$4.2M
EBV gB Function in Viral Fusion, Entry, and EgressR01AI067048 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LONGNECKER, RICHARD M · 2007 to 2011
$1.9M
HERPESVIRUS GENE EXPRESSION IN TRANSFORMED CELLSR37CA021776 · NCI · UNIVERSITY OF CHICAGO · PI SPEAR, PATRICIA G · 1987 to 1994
–
NCI NIH HHS CA021776NCI NIH HHS R01 CA021776NIAID NIH HHS AI067048NIAID NIH HHS R01 AI067048NIAID NIH HHS R01 AI076183
6 · The paper itself

Abstract

Among the herpesvirus glycoprotein B (gB) fusion proteins, the hydrophobic content of fusion loops and membrane proximal regions (MPRs) are inversely correlated with each other. We examined the functional importance of the hydrophobicity of these regions by replacing them in herpes simplex virus type 1 gB with corresponding regions from Epstein-Barr virus gB. We show that fusion activity is dependent on the structural context in which the specific loops and MPR sequences exist, rather than a simple hydrophobic relationship.

Indexed as

Amino Acid MotifsAmino Acid SequenceAnimalsCell LineCHO CellsCricetinaeHerpesvirus 1, HumanHerpesvirus 4, HumanHumansModels, MolecularMolecular Sequence DataProtein ConformationSequence AlignmentViral Envelope Proteinsglycoprotein B, SimplexvirusViral Envelope Proteins

Identifiers

PMID23089849
PMCPMC3557662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.