ArticleAntimicrobial agents and chemotherapy2013
Stepwise development of a homozygous S80P substitution in Fks1p, conferring echinocandin resistance in Candida tropicalis.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Short Tandem Repeat Genotyping and Antifungal Susceptibility Testing of Latin AmericanJournal of fungi (Basel, Switzerland) · 2023Article
- The emerging threat antifungal-resistantFrontiers in fungal biology · 2022Review
- Continual Decline in Azole Susceptibility Rates inFrontiers in microbiology · 2021Article
- The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2020Review
- Breakthrough Bloodstream Infections Caused by Echinocandin-ResistantJournal of fungi (Basel, Switzerland) · 2020Article
- EUCAST Reference Testing of Rezafungin Susceptibility and Impact of Choice of Plastic Plates.Antimicrobial agents and chemotherapy · 2019Article
- Chemical compositions and antifungal activities ofCurrent medical mycology · 2019Article
- Portrait of Matrix Gene Expression in Candida glabrata Biofilms with Stress Induced by Different Drugs.Genes · 2018Article
- Update from a 12-Year Nationwide Fungemia Surveillance: Increasing Intrinsic and Acquired Resistance Causes Concern.Journal of clinical microbiology · 2018Article
- Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy.Antimicrobial agents and chemotherapy · 2018Article
- Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistantInfection and drug resistance · 2018Article
- Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi.Mediators of inflammation · 2017Review
- An Update onFrontiers in microbiology · 2017Review
- Echinocandin Resistance in Candida Species: a Review of Recent Developments.Current infectious disease reports · 2016Review
- Posttreatment Antifungal Resistance among Colonizing Candida Isolates in Candidemia Patients: Results from a Systematic Multicenter Study.Antimicrobial agents and chemotherapy · 2015Article
- Clinical perspectives on echinocandin resistance among Candida species.Current opinion in infectious diseases · 2015Review
- [Strategies for antifungal treatment failure in intensive care units].Der Anaesthesist · 2015Review
- Mechanisms of echinocandin antifungal drug resistance.Annals of the New York Academy of Sciences · 2015Review
- Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans.Journal of clinical microbiology · 2015Article
- Echinocandin resistance: an emerging clinical problem?Current opinion in infectious diseases · 2014Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Three Candida tropicalis isolates were obtained from a patient with acute lymphoblastic leukemia. The first isolate was susceptible to all drug classes, while isolates 2 and 3, obtained after 8 and 8.5 weeks of caspofungin treatment, respectively, were resistant to the three echinocandins. Multilocus sequence genotyping suggested a clonal relation among all isolates. FKS1 sequencing revealed a stepwise development of a heterozygous and finally a homozygous mutation, leading to S80S/P and S80P amino acid substitutions.
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