ArticleMolecular psychiatry2013
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.
Article in Molecular psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 7 of them syntheses that pooled it.
What it found
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Who cites it
62 citing papers in PubMed, 7 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders.Molecular psychiatry · 2023Pooled it
- Mechanistic Characterization ofFrontiers in immunology · 2019Pooled it
- Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.Biological psychiatry · 2018Pooled it
- Endosomal system genetics and autism spectrum disorders: A literature review.Neuroscience and biobehavioral reviews · 2016Pooled it
- Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.Alcoholism, clinical and experimental research · 2015Pooled it
- Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Pooled it
- A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Human genetics · 2013Pooled it
- Charcot-Marie-Tooth gene, SBF2, associated with taxane-induced peripheral neuropathy in African Americans.Oncotarget · 2016Trial
- Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction.Alcohol, clinical & experimental research · 2024Article
- Human genetics and epigenetics of alcohol use disorder.The Journal of clinical investigation · 2024Review
- Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder.medRxiv : the preprint server for health sciences · 2024Article
- Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence.Research square · 2024Article
- The collaborative study on the genetics of alcoholism: Genetics.Genes, brain, and behavior · 2023Review
- The Collaborative Study on the Genetics of Alcoholism: Overview.Genes, brain, and behavior · 2023Review
- 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics.Genes, brain, and behavior · 2023Review
- Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features.Behavioral sciences (Basel, Switzerland) · 2023Article
- The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse.Development and psychopathology · 2022Article
- New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork.Genes · 2022Article
- A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.Molecular psychiatry · 2021Article
- The Link between Type 2 Diabetes Mellitus and the Polymorphisms of Glutathione-Metabolizing Genes Suggests a New Hypothesis Explaining Disease Initiation and Progression.Life (Basel, Switzerland) · 2021Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
37 authors at 12 institutions in 2 countries.
Funding
Abstract
Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present study was to perform a genome-wide association study (GWAS) in extended families from the Collaborative Study on the Genetics of Alcoholism to identify novel genes affecting risk for alcohol dependence (AD). To maximize the power of the extended family design, we used a quantitative endophenotype, measured in all individuals: number of alcohol-dependence symptoms endorsed (symptom count (SC)). Secondary analyses were performed to determine if the single nucleotide polymorphisms (SNPs) associated with SC were also associated with the dichotomous phenotype, DSM-IV AD. This family-based GWAS identified SNPs in C15orf53 that are strongly associated with DSM-IV alcohol-dependence symptom counts (P=4.5 × 10(-8), inflation-corrected P=9.4 × 10(-7)). Results with DSM-IV AD in the regions of interest support our findings with SC, although the associations were less significant. Attempted replications of the most promising association results were conducted in two independent samples: nonoverlapping subjects from the Study of Addiction: Genes and Environment (SAGE) and the Australian Twin Family Study of AUDs (OZALC). Nominal association of C15orf53 with SC was observed in SAGE. The variant that showed strongest association with SC, rs12912251 and its highly correlated variants (D'=1, r(2) 0.95), have previously been associated with risk for bipolar disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.