Evidence map›Paper›PMID 23089630›Full record

ArticleMolecular psychiatry2013

Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression.

F Lamers, N Vogelzangs, K R Merikangas, P de Jonge, A T F Beekman, B W J H Penninx

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 300 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02034136 naunknown statusnot on this mapstarted 2014, after this paper: background citation

Effects of Ginsenoside Supplementation on Insulin Resistance and Cardiometabolic Risk Factors in Men With Metabolic Syndrome: a Randomized Controlled Trial.

TypeinterventionalSponsorCHA UniversityRan2014 to 2014Enrolled60ConditionsMetabolic SyndromeArmsGinsenoside, Dietary fiber fill
NCT04810572 nacompletednot on this mapstarted 2021, after this paper: background citation

Evaluation of the Effects of a Nutraceutical Composition Containing Derivatives From Natural Products on the Modulation of the Endocrine Neuroimmune Axis - Translational Study.

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2021 to 2022Enrolled162ConditionsInsulin Resistance, Inflammatory Bowel Diseases, Overweight and Obesity, HealthyArmsComposition with Silymarin, Low-mineral composition without Silymarin
3 · Its place in the literature

Who cites it

300 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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240 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

F LamersGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-3720, USA. lamersf@mail.nih.gov
N Vogelzangs
K R Merikangas
P de Jonge
A T F Beekman
B W J H Penninx

Funding

Intramural NIH HHS
6 · The paper itself

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatly among individual studies. A potentially important factor explaining variability is heterogeneity of MDD. Aim of this study was to evaluate the association between depressive subtypes (based on latent class analysis) and biological measures. Data from 776 persons from the Netherlands Study of Depression and Anxiety, including 111 chronic depressed persons with melancholic depression, 122 with atypical depression and 543 controls were analyzed. Inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-α), metabolic syndrome components, body mass index (BMI), saliva cortisol awakening curves (area under the curve with respect to the ground (AUCg) and with respect to the increase (AUCi)), and diurnal cortisol slope were compared among groups. Persons with melancholic depression had a higher AUCg and higher diurnal slope compared with persons with atypical depression and with controls. Persons with atypical depression had significantly higher levels of inflammatory markers, BMI, waist circumference and triglycerides, and lower high-density lipid cholesterol than persons with melancholic depression and controls. This study confirms that chronic forms of the two major subtypes of depression are associated with different biological correlates with inflammatory and metabolic dysregulation in atypical depression and HPA-axis hyperactivity in melancholic depression. The data provide further evidence that chronic forms of depressive subtypes differ not only in their symptom presentation, but also in their biological correlates. These findings have important implications for future research on pathophysiological pathways of depression and treatment.

Indexed as

AdolescentAdultAgedBody Mass IndexCohort StudiesC-Reactive ProteinDepressionEncephalitisEnzyme-Linked Immunosorbent AssayFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemInterleukin-6MaleMetabolic DiseasesC-Reactive ProteinHydrocortisoneInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID23089630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.