ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Contribution of pulmonary KLRG1(high) and KLRG1(low) CD8 T cells to effector and memory responses during influenza virus infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Impact of etonogestrel implant use on T-cell and cytokine profiles in the female genital tract and blood.PloS one · 2020Trial
- The diverse effects of transforming growth factor-β and SMAD signaling pathways during the CTL response.Frontiers in immunology · 2023Review
- CTLs Get SMAD When Pathogens Tell Them Where to Go.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV.International journal of biological sciences · 2022Article
- Chitosan Nanovaccines as Efficient Carrier Adjuvant System for IL-12 with Enhanced Protection Against HBV.International journal of nanomedicine · 2021Article
- Cytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challenges.British journal of pharmacology · 2017Review
- Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8European journal of immunology · 2017Article
- Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity.Oncotarget · 2017Article
- Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs.Journal of leukocyte biology · 2016Review
- Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden.Immunology · 2016Article
- Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model.Vaccine · 2015Article
- Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- KLRG+ invariant natural killer T cells are long-lived effectors.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity.Cancer research · 2014Article
- Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection.Current immunology reviews · 2013Article
- High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In response to pathogen insult, CD8 T cells undergo expansion and a dynamic differentiation process into functionally different subpopulations. In this study, we show that during the effector response to influenza virus infection lung CD8 T cell subsets expressing killer cell lectin-like receptor G1 (KLRG1)(high) or KLRG1(low) had similar effector functions and immediate recall efficacy. The KLRG1 expression profile of lung CD8 T cells was not permanent after adoptive transfer and recall. Airway CD8 T cells exhibited a unique phenotype expressing low levels of KLRG1 together with high levels of markers of cellular activation. We investigated the functional characteristics of these cells by analyzing their capacity to survive and to respond to a secondary challenge outside of the airway environment. KLRG1(high) CD8 T cells isolated from the lung during the peak of the effector T cell response could survive for more than a month in the absence of cognate viral Ags after systemic adoptive transfer, and these "rested" CD8 T cells proliferated and participated in a recall response to influenza virus infection. These data highlight the unique phenotype and plasticity of effector CD8 T cell responses in the lung.
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