ArticleFree radical biology & medicine2013
Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function.
Article in Free radical biology & medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children.European journal of nutrition · 2019Trial
- Age-associated methionine sulfoxide reductase A protects against valvular interstitial cell senescence and valvular calcification.GeroScience · 2026Article
- Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction.GeroScience · 2023Article
- Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA).Scientific reports · 2022Article
- Metabolomic Profiles in Childhood and Adolescence Are Associated with Fetal Overnutrition.Metabolites · 2022Article
- Can antioxidants be effective therapeutics for type 2 diabetes?Yeungnam University journal of medicine · 2021Article
- Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice.Redox biology · 2021Article
- Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle.Aging pathobiology and therapeutics · 2020Article
- Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.EMBO molecular medicine · 2019Article
- Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.Free radical research · 2017Article
- Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice.Redox biology · 2016Article
- Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice.Physiological reports · 2016Article
- Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?Antioxidants (Basel, Switzerland) · 2016Review
- Article
- PEP-1-MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice.Journal of translational medicine · 2015Article
- Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice.Archives of biochemistry and biophysics · 2015Article
- Methionine sulfoxide reductase 2 reversibly regulates Mge1, a cochaperone of mitochondrial Hsp70, during oxidative stress.Molecular biology of the cell · 2015Article
- MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice.PloS one · 2015Article
- Revisiting an age-old question regarding oxidative stress.Free radical biology & medicine · 2014Review
- Genetics of oxidative stress in obesity.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Oxidative stress plays a significant role in the development of insulin resistance; however, the cellular targets of oxidation that cause insulin resistance have yet to be fully elucidated. Methionine sulfoxide reductases reduce oxidized methionine residues, thereby repairing and protecting proteins from oxidation. Recently, several genome-wide analyses have found human obesity to be strongly correlated with polymorphisms near the methionine sulfoxide reductase A (MsrA) locus. In this study, we tested whether modulation of MsrA expression significantly alters the development of obesity and/or insulin resistance in mice. We show that mice lacking MsrA (MsrA(-/-)) are prone to the development of high-fat-diet-induced insulin resistance and a reduced physiological insulin response compared to high-fat-fed wild-type mice. We also show that oxidative stress in C2C12 cell cultures reduces both insulin-stimulated phosphorylation and autophosphorylation of the insulin receptor. Tissues from high-fat-fed mice show similar reduction in insulin receptor function and increase in insulin receptor oxidation, which are further exacerbated by the lack of MsrA. Together, these data demonstrate for the first time that MsrA and protein oxidation play a role in the regulation of glucose homeostasis. In addition, these data support a novel hypothesis that obesity-induced insulin resistance is caused in part by reduced function of insulin signaling proteins arising from protein oxidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.