SynthesisBMJ (Clinical research ed.)2012
Neglected tropical diseases: survey and geometry of randomised evidence.
Synthesis in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Immunological Activity of Vaccine Systems Containing Liposomal Nanocarriers against Protozoan-induced Diseases: A Systematic Review.Current medicinal chemistry · 2025Pooled it
- The role of social determinants of health in the risk and prevention of group A streptococcal infection, acute rheumatic fever and rheumatic heart disease: A systematic review.PLoS neglected tropical diseases · 2018Pooled it
- Amidst spreading infectious diseases and climate change, US FDA should renew its focus on neglected tropical diseases.PLoS neglected tropical diseases · 2024Article
- Interventions for ulceration and other skin changes caused by nerve damage in leprosy.The Cochrane database of systematic reviews · 2019Review
- A very rare case: Hydatid cyst surrounding uterus and magnetic resonance imaging findings in the pregnant patient.Radiology case reports · 2019Article
- Neglected tropical diseases in children: An assessment of gaps in research prioritization.PLoS neglected tropical diseases · 2019Article
- In vitro evaluation of photodynamic therapy using curcumin on Leishmania major and Leishmania braziliensis.Lasers in medical science · 2016Article
- Dracunculiasis in oral and maxillofacial surgery.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2016Review
- Generating Evidence to Improve the Response to Neglected Diseases: How Operational Research in a Médecins Sans Frontières Buruli Ulcer Treatment Programme Informed International Management Guidance.PLoS neglected tropical diseases · 2015Article
- Article
- Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses.Bulletin of the World Health Organization · 2014Review
- Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis.BMC medicine · 2014Review
- Article
- Geometry of the randomized evidence for treatments of pulmonary hypertension.Cardiovascular therapeutics · 2013Article
- Global health: the importance of evidence-based medicine.BMC medicine · 2013Article
- Has the NTD community neglected evidence-based policy?PLoS neglected tropical diseases · 2013Article
- The effects of industry sponsorship on comparator selection in trial registrations for neuropsychiatric conditions in children.PloS one · 2013Article
- An imported case of echinococcosis in a pregnant lady with unusual presentation.Case reports in infectious diseases · 2013Article
- Identifying gaps in research prioritization: The global burden of neglected tropical diseases as reflected in the Cochrane database of systematic reviews.Journal of family medicine and primary careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess the quantity and distribution of evidence from randomised controlled trials for the treatment of the major neglected tropical diseases and to identify gaps in the evidence with network analysis.
designSystematic review and network analysis. DATA SOURCES: Cochrane Central Register of Controlled Trials and PubMed from inception to 31 August 2011. STUDY SELECTION: Randomised controlled trials that examined treatment of 16 neglected tropical diseases or complications thereof published in English, French, Spanish, Portuguese, German, or Dutch.
resultsWe identified 971 eligible randomised trials. Leishmaniasis (184 trials, 23,039 participants) and geohelminth infections; 160 trials, 46,887 participants) were the most studied, while dracunculiasis (nine trials, 798 participants) and Buruli ulcer (five trials, 337 participants) were least studied. Relative to its global burden of disease, lymphatic filariasis had the fewest trials and participants. Only 11% of trials were industry funded. Either a single trial or trials with fewer than 100 participants comprised the randomised evidence for first or second line treatments for Buruli ulcer, human African trypanosomiasis, American trypanosomiasis, cysticercosis, rabies, echinococcosis, New World cutaneous leishmaniasis, and each of the foodborne trematode infections. Among the 10 disease categories with more than 40 trials, five lacked sufficient head to head comparisons between first or second line treatments.
conclusionsThere is considerable variation in the amount of evidence from randomised controlled trials for each of the 16 major neglected tropical diseases. Even in diseases with substantial evidence, such as leishmaniasis and geohelminth infections, some recommended treatments have limited supporting data and lack head to head comparisons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.