ArticleNeuropsychologia2012
Language and reading skills in school-aged children and adolescents born preterm are associated with white matter properties on diffusion tensor imaging.
Article in Neuropsychologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reading abilities in preterm children: a systematic review and meta-analysis.Cognitive processing · 2024Pooled it
- Language outcome related to brain structures in school-aged preterm children: A systematic review.PloS one · 2018Pooled it
- Memory reactivation during rest supports upcoming learning of related content.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Role of diffusion tensor imaging as an independent predictor of cognitive and language development in extremely low-birth-weight infants.AJNR. American journal of neuroradiology · 2014Trial
- Reading and White Matter Development: A Systematic Review of Neuroplastic Changes in Literacy.Children (Basel, Switzerland) · 2025Review
- Impact of Prematurity and Neonatal Complications on the Development of Dyslexia.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Functional connectivity between the uncinate fasciculus and frontotemporal semantic system supports reading comprehension in adolescents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia.Journal of neurology · 2024Review
- Perinatal influences on academic achievement and the developing brain: a scoping systematic review.Frontiers in psychology · 2024Article
- Subtle microstructural alterations in white matter tracts involved in socio-emotional processing after very preterm birth.NeuroImage. Clinical · 2024Article
- Properties of white matter tract diffusivity in children with developmental dyslexia and comorbid attention deficit/hyperactivity disorder.Journal of neurodevelopmental disorders · 2023Article
- Associations between early efficiency in language processing and language and cognitive outcomes in children born full term and preterm: similarities and differences.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2023Article
- Neuroimaging of brain connectivity related to reading outcomes in children born preterm: A critical narrative review.Frontiers in pediatrics · 2023Review
- Language function following preterm birth: prediction using machine learning.Pediatric research · 2022Article
- Associations Between White Matter Microstructures and Cognitive Functioning in 8-Year-Old Children: A Track-Weighted Imaging Study.Journal of child neurology · 2022Article
- A large-scale investigation of white matter microstructural associations with reading ability.NeuroImage · 2022Article
- Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: The MagNUM Study.EBioMedicine · 2022Article
- Sociodemographic and socioeconomic correlates of learning disability in preterm children in the United States.BMC public health · 2022Article
- The role of diffusion tensor imaging in idiopathic sensorineural hearing loss: is it significant?Polish journal of radiology · 2021Article
- Assessing speech exposure in the NICU: Implications for speech enrichment for preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Children born preterm are at risk for deficits in language and reading. They are also at risk for injury to the white matter of the brain. The goal of this study was to determine whether performance in language and reading skills would be associated with white matter properties in children born preterm and full-term. Children born before 36 weeks gestation (n=23, mean±SD age 12.5±2.0 years, gestational age 28.7±2.5 weeks, birth weight 1184±431 g) and controls born after 37 weeks gestation (n=19, 13.1±2.1 years, 39.3±1.0 weeks, 3178±413 g) underwent a battery of language and reading tests. Diffusion tensor imaging (DTI) scans were processed using tract-based spatial statistics to generate a core white matter skeleton that was anatomically comparable across participants. Fractional anisotropy (FA) was the diffusion property used in analyses. In the full-term group, no regions of the whole FA-skeleton were associated with language and reading. In the preterm group, regions of the FA-skeleton were significantly associated with verbal IQ, linguistic processing speed, syntactic comprehension, and decoding. Combined, the regions formed a composite map of 22 clusters on 15 tracts in both hemispheres and in the ventral and dorsal streams. ROI analyses in the preterm group found that several of these regions also showed positive associations with receptive vocabulary, verbal memory, and reading comprehension. Some of the same regions showed weak negative correlations within the full-term group. Exploratory multiple regression in the preterm group found that specific white matter pathways were related to different aspects of language processing and reading, accounting for 27-44% of the variance. The findings suggest that higher performance in language and reading in a group of preterm but not full-term children is associated with higher fractional anisotropy of a bilateral and distributed white matter network.
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