Observational studyCritical care (London, England)2012
Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis.
Observational study in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Effect of thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review.Critical care (London, England) · 2014Pooled it
- Early Platelet Dysfunction in Sepsis: An ICU Pilot Study.Pathogens (Basel, Switzerland) · 2026Observational
- Article
- Platelet P2YBritish journal of pharmacology · 2024Review
- Article
- Early SARS-CoV-2 infection: Platelet-neutrophil complexes and platelet function.Research and practice in thrombosis and haemostasis · 2023Article
- IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis.The Journal of clinical investigation · 2022Article
- Elevated Pre- and Postoperative ROTEM™ Clot Lysis Indices Indicate Reduced Clot Retraction and Increased Mortality in Patients Undergoing Liver Transplantation.Biomedicines · 2022Article
- Activated platelets and platelet-leukocyte aggregates in the equine systemic inflammatory response syndrome.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience.Brain, behavior, & immunity - health · 2022Review
- Questions about COVID-19 associated coagulopathy: possible answers from the viscoelastic tests.Journal of clinical monitoring and computing · 2022Review
- Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis.PloS one · 2022Article
- Platelet Reactivity and Coagulation Markers in Patients with COVID-19.Advances in therapy · 2021Article
- Role of thromboelastography in the evaluation of septic shock patients with normal prothrombin time and activated partial thromboplastin time.Scientific reports · 2021Observational
- Assessment of platelet biology in equine patients with systemic inflammatory response syndrome.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- COVID-19-associated Coagulopathy.Anesthesiology · 2021Article
- The role of platelets in sepsis.Research and practice in thrombosis and haemostasis · 2021Article
- COVID-19-Associated Coagulopathy and Inflammatory Response: What Do We Know Already and What Are the Knowledge Gaps?Anesthesia and analgesia · 2020Review
- Whole-blood hypocoagulable profile correlates with a greater risk of death within 28 days in patients with severe sepsis.Korean journal of anesthesiology · 2020Article
- Emerging role of the point-of-care coagulation test in sepsis.Korean journal of anesthesiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSepsis leads to an activation of the immune system and hemostatis. However, studies on platelet aggregation in severe sepsis using impedance aggregometry have not been performed and the diagnostic and prognostic capabilities are unknown. In the present study we hypothesized that impedance aggregometry findings might serve as a biomarker for the diagnosis and prognosis of severe sepsis.
methodsEighty patients with severe sepsis and 50 postoperative patients were included in the prospective observational study. Platelet function was determined at the first day of severe sepsis and surgery, respectively, using impedance aggregometry (Multiplate®). Moreover, platelet count, procalcitonin, interleukin 6, C-reactive protein and 30-day mortality were determined.
resultsCompared to postoperative patients, platelet aggregation was significantly reduced in patients with severe sepsis (collagen-test: 70.8 (44.4, 83.2) arbitrary units (A.U.) vs. 26.8 (12.7, 45.8) A.U.; P <0.001; median and quartiles). Furthermore, marked differences in platelet function were observed in survivors and non-survivors of severe sepsis (collagen-test: 33.4 (10.9, 48.8) A.U. vs. 12.4 (6.5, 25.0) A.U.; P = 0.001). Kaplan-Meier analysis demonstrated that higher platelet function was associated with a mortality of 10%, while mortality was 40% when platelet function was low (collagen-test; P = 0.002). The odds ratio was 6.0. In both univariate and multivariate analyses (including procalcitonin, IL6, C-reactive protein and platelet count) impedance aggregometry using collagen as the activator proved to be the best and an independent predictor for the diagnosis and prognosis of severe sepsis in critical illness.
conclusionsIn severe sepsis, impedance aggregometry allows better prediction of diagnosis and survival than conventional biomarkers and platelet count.
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