ArticleIndian journal of endocrinology and metabolism2012
Celiac disease: A missed cause of metabolic bone disease.
Article in Indian journal of endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow-Up, and Complex Disease Courses.United European gastroenterology journal · 2026Guideline
- Celiac disease - a pluripathological model in pediatric practice.Frontiers in immunology · 2024Review
- The Dietary and Non-Dietary Management of Osteoporosis in Adult-Onset Celiac Disease: Current Status and Practical Guidance.Nutrients · 2022Review
- Emergence of Celiac disease and Gluten-related disorders in Asia.Journal of neurogastroenterology and motility · 2021Review
- Genome sequence and comparative genomic analysis of a clinically important strain CD11-4 ofGut pathogens · 2018Article
- Sequential testing with different tissue transglutaminase antibodies, a new approach for diagnosis of celiac disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- Comparative study of clinical features of patients with celiac disease & those with concurrent celiac disease & type 1 diabetes mellitus.The Indian journal of medical research · 2017Article
- Child with multiple fractures: a rare presentation of a common disease.BMJ case reports · 2017Article
- Is it necessary to screen for celiac disease in adult idiopathic osteoporosis?Gastroenterology and hepatology from bed to bench · 2015Article
- Celiac disease and risk of fracture in adults--a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- The clinical presentation of celiac disease: experiences from northeastern iran.Middle East journal of digestive diseases · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCeliac disease (CD) is a highly prevalent autoimmune disease. The symptoms of CD are varied and atypical, with many patients having no gastrointestinal symptoms. Metabolic bone disease (MBD) is a less recognized manifestation of CD associated with spectrum of musculoskeletal signs and symptoms, viz. bone pains, proximal muscle weakness, osteopenia, osteoporosis, and fracture. We here report five patients who presented with severe MBD as the only manifestation of CD. MATERIALS AND
methodsRecords of 825 patients of CD diagnosed during 2002-2010 were retrospectively analyzed for clinical features, risk factors, signs, biochemical, and radiological parameters.
resultsWe were able to identify five patients (0.6%) of CD who had monosymptomatic presentation with musculoskeletal symptoms and signs in the form of bone pains, proximal myopathy, and fragility fractures without any gastrointestinal manifestation. All the five patients had severe MBD in the form of osteopenia, osteoporosis, and fragility fractures. Four of the five patients had additional risk factors such as antiepileptic drugs, chronic alcohol consumption, malnutrition, and associated vitamin D deficiency which might have contributed to the severity of MBD.
conclusionSevere metabolic disease as the only presentation of CD is rare. Patients show significant improvement in clinical, biochemical, and radiological parameters with gluten-free diet, calcium, and vitamin D supplementation. CD should be looked for routinely in patients presenting with unexplained MBD.
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