Evidence map›Paper›PMID 23087835›Full record

ArticleSpermatogenesis2012

Transcriptional regulation during Drosophila spermatogenesis.

Cindy Lim, Lama Tarayrah, Xin Chen

Open access · bronzeAbstract read
In one paragraph

Article in Spermatogenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  7. Deficiency ofInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Single-cyst transcriptome analysis ofDevelopment (Cambridge, England) · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Asymmetric distribution of histones during Drosophila male germline stem cell asymmetric divisions.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013
    Review
  20. Protamines and spermatogenesis inSpermatogenesis · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Cindy LimDepartment of Biology; The Johns Hopkins University; Baltimore, MD USA.
Lama Tarayrah
Xin Chen
Johns Hopkins Medicine · USJohns Hopkins University · USUniversity of Baltimore · US

Funding

Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell LineageR01HD065816 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2011 to 2015
$1.6M
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell LineageR00HD055052 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2008 to 2010
$745k
Epigenetic inheritance in germline stem cell lineageR21HD065089 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2010 to 2011
$380k
Investigating the role of dUTX in Drosophila male germ cell differentiationF31CA165781 · NCI · JOHNS HOPKINS UNIVERSITY · PI TARAYRAH, LAMA · 2011 to 2014
$127k
NCI NIH HHS F31 CA165781NICHD NIH HHS R00 HD055052NICHD NIH HHS R01 HD065816NICHD NIH HHS R21 HD065089
6 · The paper itself

Abstract

Drosophila spermatogenesis has become a paradigmatic system for the study of mechanisms that regulate adult stem cell maintenance, proliferation and differentiation. The dramatic cellular differentiation process from germline stem cell (GSC) to mature sperm is accompanied by dynamic changes in gene expression, which are regulated at transcriptional, post-transcriptional (including translational) and post-translational levels. Post-transcriptional regulation has been proposed as a unique feature of germ cells. However, recent studies have provided new insights into transcriptional regulation during Drosophila spermatogenesis. Both signaling pathways and epigenetic mechanisms act to orchestrate the transcriptional regulation of distinct genes at different germ cell differentiation stages. Many of the regulatory pathways that control male gamete differentiation in Drosophila are conserved in mammals. Therefore, studies using Drosophila spermatogenesis will provide insight into the molecular mechanisms that regulate mammalian germ cell differentiation pathways.

Identifiers

PMID23087835
PMCPMC3469439
OpenAlexW2040850361

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.