ArticleFrontiers in genetics2012
Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03353597 (Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects
Who cites it
32 citing papers in PubMed.
- Multilayered regulation of longevity in Caenorhabditis elegans.Molecules and cells · 2026Review
- Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling.Nature communications · 2025Article
- Article
- An insulin-like signalling pathway model for Fasciola gigantica.BMC veterinary research · 2024Article
- Culturomic-, metagenomic-, and transcriptomic-based characterization of commensal lactic acid bacteria isolated from domestic dogs using Caenorhabditis elegans as a model for aging.Journal of animal science · 2022Article
- Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling inMolecules and cells · 2022Review
- The Thermal Stress Coping Network of the NematodeInternational journal of molecular sciences · 2022Review
- The hypothalamus for whole-body physiology: from metabolism to aging.Protein & cell · 2022Review
- Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans.BMC biology · 2022Article
- Eyeless Worms Can Run Away from Dangerous Blues.Molecules and cells · 2021Article
- Combinatorial Approach UsingMolecules and cells · 2021Review
- Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30.Cell reports · 2021Article
- GABA receptors differentially regulate life span and health span inAmerican journal of physiology. Cell physiology · 2019Article
- Neuronal microtubules impact lifespan.Aging · 2019Article
- MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis.PLoS biology · 2019Article
- Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO inGenes & development · 2018Article
- skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans.PloS one · 2017Article
- A novel role for the 3'-5' exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth.RNA biology · 2016Article
- The odor of a plant metabolite affects life history traits in dietary restricted adult olive flies.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many environmental factors that dynamically change in nature influence various aspects of animal physiology. Animals are equipped with sensory neuronal systems that help them properly sense and respond to environmental factors. Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster. Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation. In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.