Evidence map›Paper›PMID 23087687›Full record

ArticleFrontiers in immunology2012

Advances in human B cell phenotypic profiling.

Denise A Kaminski, Chungwen Wei, Yu Qian, Alexander F Rosenberg, Ignacio Sanz

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02294032 (The Role of B Cells in Kidney Allograft Dysfunction), which is not on this map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02294032 completednot on this mapstarted 2014, after this paper: background citation

The Role of B Cells in Kidney Allograft Dysfunction

Typeobservational_patient_registrySponsorLoma Linda UniversityRan2014 to 2023Enrolled180ConditionsKidney, Complications, Allograft, Transplantation InfectionArmsImmunosuppressive Agents
3 · Its place in the literature

Who cites it

146 citing papers in PubMed.

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  9. Article
  10. Cross-presentation of citrullinated antigens drives cytotoxic CD8bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Single-cell atlas of grass carp (Zoological research · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Denise A KaminskiDivision of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester Rochester, NY, USA.
Chungwen Wei
Yu Qian
Alexander F Rosenberg
Ignacio Sanz

Funding

UNIVERSITY OF ROCHESTER'S RESEARCH ASSOCIATE ORGANIZATIONUL1RR024160 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$38.7M
Role of B Cells in Synovial Inflammation & LN Remodeling in RA ArthritisP01AI078907 · NIAID · UNIVERSITY OF ROCHESTER · PI LUND, FRANCES E. · 2010 to 2014
$10.8M
Translational Research Project Effector and Regulatory B cells in SLEU19AI056390 · NIAID · UNIVERSITY OF ROCHESTER · PI MOSMANN, TIM R. · 2003 to 2013
$8.9M
A Model System for the Study of Human B-cell ToleranceR37AI049660 · NIAID · UNIVERSITY OF ROCHESTER · PI SANZ, IGNACIO E. · 2010 to 2019
$3.7M
IMMUNE FUNCTION AND BIODEFENSE IN CHILDREN. ELDERLY AND IMMUNOCOMPROMI-266050029N01AI050029 · NIAID · UNIVERSITY OF ROCHESTER · PI SANZ, IGNACIO E. · 2006 to 2006
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NCRR NIH HHS UL1 RR024160NIAID NIH HHS N01 AI040076NIAID NIH HHS P01 AI078907NIAID NIH HHS R37 AI049660NIAID NIH HHS U19 AI056390
6 · The paper itself

Abstract

To advance our understanding and treatment of disease, research immunologists have been called-upon to place more centralized emphasis on impactful human studies. Such endeavors will inevitably require large-scale study execution and data management regulation ("Big Biology"), necessitating standardized and reliable metrics of immune status and function. A well-known example setting this large-scale effort in-motion is identifying correlations between eventual disease outcome and T lymphocyte phenotype in large HIV-patient cohorts using multiparameter flow cytometry. However, infection, immunodeficiency, and autoimmunity are also characterized by correlative and functional contributions of B lymphocytes, which to-date have received much less attention in the human Big Biology enterprise. Here, we review progress in human B cell phenotyping, analysis, and bioinformatics tools that constitute valuable resources for the B cell research community to effectively join in this effort.

Indexed as

autoimmunityB lymphocytedata clusteringdata managementflow cytometryhuman

Identifiers

PMID23087687
PMCPMC3467643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.