ArticleFrontiers in neuroanatomy2012
Communication and wiring in the cortical connectome.
Article in Frontiers in neuroanatomy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Mechanistic versus descriptive interpretation of brain activity pattern reconstruction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Decrease in phase slip rates and phase cone structures during seizure evolution and epileptogenic activities derived from microgrid ECoG data.Current research in neurobiology · 2024Article
- The neuroanatomical organization of the hypothalamus is driven by spatial and topological efficiency.Frontiers in systems neuroscience · 2024Article
- Spatiotemporal phase slip patterns for visual evoked potentials, covert object naming tasks, and insight moments extracted from 256 channel EEG recordings.Frontiers in integrative neuroscience · 2023Article
- Toward reframing brain-social dynamics: current assumptions and future challenges.Frontiers in psychiatry · 2023Review
- Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring.International journal of molecular sciences · 2020Article
- Open access resource for cellular-resolution analyses of corticocortical connectivity in the marmoset monkey.Nature communications · 2020Article
- ROOTS: An Algorithm to Generate Biologically Realistic Cortical Axons and an Application to Electroceutical Modeling.Frontiers in computational neuroscience · 2020Article
- High-resolution imaging of distinct human corpus callosum microstructure and topography of structural connectivity to cortices at high field.Brain structure & function · 2019Article
- Gotta Trace 'em All: A Mini-Review on Tools and Procedures for Segmenting Single Neurons Toward Deciphering the Structural Connectome.Frontiers in bioengineering and biotechnology · 2019Review
- Experimental Traumatic Brain Injury Identifies Distinct Early and Late Phase Axonal Conduction Deficits of White Matter Pathophysiology, and Reveals Intervening Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- An Optimized Structure-Function Design Principle Underlies Efficient Signaling Dynamics in Neurons.Scientific reports · 2018Article
- Graph-Based Models of Cortical Axons for the Prediction of Neuronal Response to Extracellular Electrical Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2018Article
- Time-dependent differences in cortical measures and their associations with behavioral measures following mild traumatic brain injury.Human brain mapping · 2018Article
- Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia.NPJ schizophrenia · 2018Article
- Oscillatory Patterns of Phase Cone Formations near to Epileptic Spikes Derived from 256-Channel Scalp EEG Data.Computational and mathematical methods in medicine · 2018Article
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Abstract
In cerebral cortex, the huge mass of axonal wiring that carries information between near and distant neurons is thought to provide the neural substrate for cognitive and perceptual function. The goal of mapping the connectivity of cortical axons at different spatial scales, the cortical connectome, is to trace the paths of information flow in cerebral cortex. To appreciate the relationship between the connectome and cortical function, we need to discover the nature and purpose of the wiring principles underlying cortical connectivity. A popular explanation has been that axonal length is strictly minimized both within and between cortical regions. In contrast, we have hypothesized the existence of a multi-scale principle of cortical wiring where to optimize communication there is a trade-off between spatial (construction) and temporal (routing) costs. Here, using recent evidence concerning cortical spatial networks we critically evaluate this hypothesis at neuron, local circuit, and pathway scales. We report three main conclusions. First, the axonal and dendritic arbor morphology of single neocortical neurons may be governed by a similar wiring principle, one that balances the conservation of cellular material and conduction delay. Second, the same principle may be observed for fiber tracts connecting cortical regions. Third, the absence of sufficient local circuit data currently prohibits any meaningful assessment of the hypothesis at this scale of cortical organization. To avoid neglecting neuron and microcircuit levels of cortical organization, the connectome framework should incorporate more morphological description. In addition, structural analyses of temporal cost for cortical circuits should take account of both axonal conduction and neuronal integration delays, which appear mostly of the same order of magnitude. We conclude the hypothesized trade-off between spatial and temporal costs may potentially offer a powerful explanation for cortical wiring patterns.
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