ArticleFrontiers in molecular neuroscience2012
Constitutively expressed Protocadherin-α regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic region.
Article in Frontiers in molecular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Protocadherin γC4 regulates neuronal survival and dendritic self-avoidance.Communications biology · 2026Article
- A New Targeted Transgenic Mouse Line for the Study of Protocadherin γC4.Genesis (New York, N.Y. : 2000) · 2025Article
- PCDHA9 as a candidate gene for amyotrophic lateral sclerosis.Nature communications · 2024Article
- Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction.Frontiers in cell and developmental biology · 2023Article
- To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly.Frontiers in neuroscience · 2022Review
- Expression of protocadherin-γC4 protein in the rat brain.The Journal of comparative neurology · 2020Article
- The protocadherin alpha cluster is required for axon extension and myelination in the developing central nervous system.Neural regeneration research · 2018Article
- ProtocadherinProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Regulation of neural circuit formation by protocadherins.Cellular and molecular life sciences : CMLS · 2017Review
- Regulation of Wnt signaling by protocadherins.Seminars in cell & developmental biology · 2017Review
- Structural origins of clustered protocadherin-mediated neuronal barcoding.Seminars in cell & developmental biology · 2017Review
- Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.Science (New York, N.Y.) · 2017Article
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- Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.Neuron · 2016Article
- Distinct and Cooperative Functions for theFrontiers in molecular neuroscience · 2016Article
- Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity.Genes & nutrition · 2015Article
- Genetic basis of neuronal individuality in the mammalian brain.Journal of neurogenetics · 2013Review
- Clustered protocadherins.Development (Cambridge, England) · 2013Review
- Protocadherins, not prototypical: a complex tale of their interactions, expression, and functions.Frontiers in molecular neuroscience · 2013Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Olfactory sensory neuron (OSN) axons coalesce into specific glomeruli in the olfactory bulb (OB) according to their odorant receptor (OR) expression. Several guidance molecules enhance the coalescence of homotypic OSN projections, in an OR-specific- and neural-activity-dependent manner. However, the mechanism by which homotypic OSN axons are organized into glomeruli is unsolved. We previously reported that the clustered protocadherin-α (Pcdh-α) family of diverse cadherin-related molecules plays roles in the coalescence and elimination of homotypic OSN axons throughout development. Here we showed that the elimination of small ectopic homotypic glomeruli required the constitutive expression of a Pcdh-α isoform and Pcdh-α's cytoplasmic region, but not OR specificity or neural activity. These results suggest that Pcdh-α proteins provide a cytoplasmic signal to regulate repulsive activity for homotypic OSN axons independently of OR expression and neural activity. The counterbalancing effect of Pcdh-α proteins for the axonal coalescence mechanisms mediated by other olfactory guidance molecules indicate a possible mechanism for the organization of homotypic OSN axons into glomeruli during development.
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