ArticlePolymer international2012
pH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Delivery of Hydrophobic Therapeutic Agents.
Article in Polymer international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- From Synthesis to Solutions: Hydrogels' Impact on the Biomedical Landscape.Current pharmaceutical biotechnology · 2025Review
- Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing.Drug delivery and translational research · 2023Article
- Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration.Gels (Basel, Switzerland) · 2022Article
- Synthesis and evaluation of chitosan based controlled release nanoparticles for the delivery of ticagrelor.Designed monomers and polymers · 2022Article
- Correlation of Bulk Degradation and Molecular Release from Enzymatically Degradable Polymeric Hydrogels.Biomacromolecules · 2021Article
- Hydrogels Classification According to the Physical or Chemical Interactions and as Stimuli-Sensitive Materials.Gels (Basel, Switzerland) · 2021Review
- Synthesis and Antimicrobial Properties of Highly Cross-Linked pH-Sensitive Hydrogels through Gamma Radiation.Polymers · 2021Article
- Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management.Pharmaceutics · 2021Review
- Nanoparticle-hydrogel superstructures for biomedical applications.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Hybrid hydrogels for biomedical applications.Current opinion in chemical engineering · 2019Article
- Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications.Drug design, development and therapy · 2019Review
- Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery.Gels (Basel, Switzerland) · 2018Article
- Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery.Acta pharmaceutica Sinica. B · 2018Review
- Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications.Journal of functional biomaterials · 2018Review
- Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents.Journal of drug delivery science and technology · 2015Article
- ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.Journal of materials chemistry. B · 2014Article
- Intelligent recognitive systems in nanomedicine.Current opinion in chemical engineering · 2014Article
- 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.Advanced materials (Deerfield Beach, Fla.) · 2014Review
- pH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics.Journal of biomedical materials research. Part A · 2013Article
- A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
To investigate the delivery of hydrophobic therapeutic agents, a new class of polymer carriers was synthesized. These carriers are composed of two components: (i) a pH-responsive hydrogel composed of methacrylic acid grafted with poly(ethylene glycol) tethers, P(MAA-g-EG), and (ii) hydrophobic poly(methyl methacrylate) (PMMA) nanoparticles. Before the P(MAA-g-EG) hydrogel was crosslinked, PMMA nanoparticles were added to the solution and upon exposure to UV light they were photoencapsulated throughout the P(MAA-g-EG) hydrogel structure. The pH-responsive behavior of P(MAA-g-EG) is capable of triggered release of a loaded therapeutic agent, such as a low molecular weight drug or protein, when it passes from the stomach (low pH) to upper small intestine (neutral pH). The introduction of PMMA nanoparticles into the hydrogel structure affected the swelling behavior, therapeutic agent loading efficiency, and solute release profiles. In equilibrium swelling conditions the swelling ratio of nanoparticle-containing hydrogels decreased with increasing nanoparticle content. Loading efficiencies of the model therapeutic agent fluorescein ranged from 38 - 51 % and increased with increasing hydrophobic content. Release studies from neat P(MAA-g-EG) and the ensuing P(MAA-g-EG) hydrogels containing nanoparticles indicated that the transition from low pH (2.0) to neutral pH (7.0) triggered fluorescein release. Maximum fluorescein release depended on the structure and hydrophobicity of the carriers used in these studies.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.