ArticleChemistry of materials : a publication of the American Chemical Society2012
Thermosensitive multilayer hydrogels of poly(N-vinylcaprolactam) as nanothin films and shaped capsules.
Article in Chemistry of materials : a publication of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Polymer-Wrapped Oil Droplets and Polymer Particles with Complex Curvilinear Polyhedral Geometries by Surfactant-Driven Elastocapillary Buckling of Polymer Capsules.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Biomembrane-Based Nanostructure- and Microstructure-Loaded Hydrogels for Promoting Chronic Wound Healing.International journal of nanomedicine · 2023Review
- Investigation and Characterization of Factors Affecting Rheological Properties of Poloxamer-Based Thermo-Sensitive Hydrogel.Polymers · 2022Article
- Article
- PPEGMEMA-based cationic copolymers designed for layer-by-layer assembly.RSC advances · 2019Article
- Effect of temperature and hydrophilic ratio on the structure of poly(N-vinylcaprolactam)-block-poly(dimethylsiloxane)-block-poly(N-vinylcaprolactam) polymersomes.ACS applied polymer materials · 2019Article
- Encapsulation and Ultrasound-Triggered Release of G-Quadruplex DNA in Multilayer Hydrogel Microcapsules.Polymers · 2018Article
- Review
- Host-Guest Chemistry in Layer-by-Layer Assemblies Containing Calix[n]arenes and Cucurbit[n]urils: A Review.Polymers · 2018Review
- Aggregation Control by Multi-stimuli-Responsive Poly(N-vinylamide) Derivatives in Aqueous System.Nanoscale research letters · 2017Article
- Article
- Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes.Acta biomaterialia · 2017Article
- Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications.Gels (Basel, Switzerland) · 2016Review
- Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunity.Advanced healthcare materials · 2015Article
- Internalization of red blood cell-mimicking hydrogel capsules with pH-triggered shape responses.ACS nano · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We report on nanothin multilayer hydrogels of cross-linked poly(N-vinylcaprolactam) (PVCL) that exhibit distinctive and reversible thermoresponsive behavior. The single-component PVCL hydrogels were produced by selective cross-linking of PVCL in layer-by-layer films of PVCL-NH(2) copolymers assembled with poly(methacrylic acid) (PMAA) via hydrogen bonding. The degree of the PVCL hydrogel film shrinkage, defined as the ratio of wet thicknesses at 25°C to 50°C, was demonstrated to be 1.9±0.1 and 1.3±0.1 for the films made from PVCL-NH(2)-7 and PVCL-NH(2)-14 copolymers, respectively. No temperature-responsive behavior was observed for non-cross-linked two-component films due to the presence of PMAA. We also demonstrated that temperature-sensitive PVCL capsules of cubical and spherical shapes could be fabricated as hollow hydrogel replicas of inorganic templates. The cubical (PVCL)(7) capsules retained their cubical shape when temperature was elevated from 25°C to 50°C exhibiting 21±1% decrease in the capsule size. Spherical hydrogel capsules demonstrated similar shrinkage of 23±1%. The temperature-triggered capsule size changes were completely reversible. Our work opens new prospects for developing biocompatible and nanothin hydrogel-based coatings and containers for temperate-regulating drug delivery, cellular uptake, sensing, and transport behavior in microfluidic devices.
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Registered trials
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