ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 91 citations in OpenAlex.
- Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Triple Latency as a Driver of Chronic Inflammation: An Integrative View of HSV, EBV, and CMV Persistence in Immunocompetent Hosts.Clinics and practice · 2026Review
- Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance.Immunity & ageing : I & A · 2025Article
- Peripheral EBV antigen-specific T cell is dysfunctional in Epstein-Barr virus positive diffuse large B-cell lymphoma.BMC cancer · 2025Article
- Neurotropic Viruses as Acute and Insidious Drivers of Aging.Biomolecules · 2025Review
- Early life thymectomy induces arterial dysfunction in mice.GeroScience · 2024Article
- The aging of the immune system and its implications for transplantation.GeroScience · 2023Review
- Contribution of viral and bacterial infections to senescence and immunosenescence.Frontiers in cellular and infection microbiology · 2023Review
- Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Acute effects of FLT3L treatment on T cells in intact mice.Scientific reports · 2022Article
- Lifelong cytomegalovirus and early-LIFE irradiation synergistically potentiate age-related defects in response to vaccination and infection.Aging cell · 2022Article
- Quantitative restoration of immune defense in old animals determined by naive antigen-specific CD8 T-cell numbers.Aging cell · 2022Article
- Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens.Cell reports · 2022Article
- Effects of Chronic Viral Infection on Lymphocyte Populations in Middle-aged Baboons (Comparative medicine · 2021Article
- Immunity to acute virus infections with advanced age.Current opinion in virology · 2021Review
- Sex- and age-dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice.Immunity & ageing : I & A · 2021Article
- Age and CMV-Infection Jointly Affect the EBV-Specific CD8Frontiers in aging · 2021Article
- How age and infection history shape the antigen-specific CD8Aging cell · 2020Review
- Impact of CMV upon immune aging: facts and fiction.Medical microbiology and immunology · 2019Review
- Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.PLoS pathogens · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Persistent CMV infection has been associated with immune senescence. To address the causal impact of lifelong persistent viral infection on immune homeostasis and defense, we infected young mice systemically with HSV-1, murine CMV, or both viruses and studied their T cell homeostasis and function. Herpesvirus(+) mice exhibited increased all-cause mortality compared with controls. Upon Listeria-OVA infection, 23-mo-old animals that had experienced lifelong herpesvirus infections showed impaired bacterial control and CD8 T cell function, along with distinct alterations in the T cell repertoire both before and after Listeria challenge, compared with age-matched, herpesvirus-free controls. Herpesvirus infection was associated with reduced naive CD8 T cell precursors above the loss attributable to aging. Moreover, the OVA-specific CD8 T cell repertoire recruited after Listeria challenge was entirely nonoverlapping between control and herpesvirus(+) mice. To our knowledge, this study for the first time causally links lifelong herpesvirus infection to all-cause mortality in mice and to disturbances in the T cell repertoire, which themselves correspond to impaired immunity to a new infection in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.