ArticleInternational immunology2013
Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins.
Article in International immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation.bioRxiv : the preprint server for biology · 2026Article
- A Comprehensive Bioinformatic Analysis Based on Functional Studies of MEF-2 Family in NSCLC.The Yale journal of biology and medicine · 2025Article
- Multimodal hierarchical classification of CITE-seq data delineates immune cell states across lineages and tissues.Cell reports methods · 2025Article
- Multimodal hierarchical classification of CITE-seq data delineates immune cell states across lineages and tissues.bioRxiv : the preprint server for biology · 2024Article
- Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene.Cancer science · 2023Article
- MEF-2 isoforms' (A-D) roles in development and tumorigenesis.Oncotarget · 2019Review
- MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis.Nature communications · 2016Article
- Article
- MEF2C and EBF1 Co-regulate B Cell-Specific Transcription.PLoS genetics · 2016Article
- Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.Oncotarget · 2015Article
- Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death.Journal of neuroinflammation · 2015Article
- Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Myocyte enhancer factor 2C in hematopoiesis and leukemia.Oncogene · 2014Review
- Identification of co-expressed gene signatures in mouse B1, marginal zone and B2 B-cell populations.Immunology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Mef2 family transcriptional regulator Mef2c (myocyte enhancer factor 2c) is highly expressed in maturing bone marrow and peripheral mature B-cells. To evaluate the role of this transcription factor in B-cell development, we generated a B-cell-specific conditional deletion of Mef2c using the Mb-1-Cre transgene that is expressed during the early stages of immunoglobulin rearrangement. Young mice possessing this defect demonstrated a significant impairment in B-cell numbers in bone marrow and spleen. This phenotype was evident in all B-cell subsets; however, as the animals mature, the deficit in the peripheral mature B-cell compartments was overcome. The absence of Mef2c in mature B-cells led to unique CD23+ and CD23- subsets that were evident in Mef2c knockout primary samples as well as Mef2c-deficient cultured, differentiated B-cells. Genome-wide expression analysis of immature and mature B-cells lacking Mef2c indicated altered expression for a number of key regulatory proteins for B-cell function including Ciita, CD23, Cr1/Cr2 and Tnfsf4. Chromatin immunoprecipitation analysis confirmed Mef2c binding to the promoters of these genes indicating a direct link between the presence (or absence) of Mef2c and altered transcriptional control in mature B-cells.
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