Evidence map›Paper›PMID 23087052›Full record

ReviewAmerican journal of respiratory cell and molecular biology2013

Humoral immunity and the development of obliterative bronchiolitis after lung transplantation: is there a link?

Amir M Emtiazjoo, David S Wilkes

Registry-linked trialAbstract readReview
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04234919 (A Longitudinal Study of Donor-Derived Cell Free DNA in Lung Transplant), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04234919 completednot on this mapstarted 2020, after this paper: background citation

A Longitudinal Study of Donor-Derived Cell Free DNA in Lung Transplant

TypeobservationalSponsorUniversity of Colorado, DenverRan2020 to 2021Enrolled24ConditionsLung Transplant Rejection
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Lessons and limits of mouse models.Cold Spring Harbor perspectives in medicine · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amir M EmtiazjooDivision of Pulmonary and Critical Care, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
David S Wilkes
Pulmonary and Critical Care Associates · US

Funding

Transgenic Mouse CoreP01AI084853 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI WILKES, DAVID S · 2010 to 2014
$7.7M
Type V Collagen Prevents Lung Allograft RejectionR01HL067177 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WILKES, DAVID S · 2001 to 2011
$3.7M
Role of anti-Col (V) immunity in primary graft dysfunctionR01HL096845 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D, WILKES, DAVID S · 2010 to 2013
$2.2M
NHLBI NIH HHS HL096845NHLBI NIH HHS R01 HL067177NHLBI NIH HHS R01HL067177NHLBI NIH HHS R01 HL096845NIAID NIH HHS P01 AI084853NIAID NIH HHS P01AI084853
6 · The paper itself

Abstract

Lung transplantation is considered the definitive treatment for many end-stage lung diseases. However, the lung is rejected more commonly than other solid organ allografts. Obliterative bronchiolitis (OB) is the leading cause of chronic allograft dysfunction, and the key reason why the 5-year survival of lung transplant recipients is only 50%. The pathophysiology of OB is incompletely understood. Although a clear role for the immune response to donor antigens has been observed (also known as anti-human leukocyte antigens), evidence is emerging about the role of autoimmunity to self-antigens. This review highlights the current understanding of humoral immunity in the development of OB after lung transplantation.

Indexed as

Antibody FormationBronchiolitis ObliteransHumansInterleukin-17Lung TransplantationSurvival RateTh17 CellsT-Lymphocytes, RegulatoryInterleukin-17

Identifiers

PMID23087052
PMCPMC3604061
OpenAlexW2034407084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.