Evidence map›Paper›PMID 23086657›Full record

ArticleInflammation2013

Retinol suppresses the activation of Toll-like receptors in MyD88- and STAT1-independent manners.

So Young Kim, Jung Eun Koo, Mi-Ryoung Song, Joo Young Lee

Abstract read
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In one paragraph

Article in Inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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  11. TNIP1 RegulatesFrontiers in immunology · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

So Young KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 500-712, Korea.
Jung Eun Koo
Mi-Ryoung Song
Joo Young Lee
Catholic University of Korea · KRGwangju Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of Toll-like receptor (TLR) activation is well known to be linked to development and aggravation of inflammatory diseases and immune disorders. Retinol is reported to participate in regulation of immune responses. However, it has not been fully understood how retinol regulates TLR activation in macrophages. Our results showed that retinol suppressed the expression of various inflammatory cytokines in bone marrow-derived macrophages stimulated with ligands of TLR2, TLR3, or TLR4. These demonstrate that inhibitory effect of retinol is not limited to a single TLR. Inhibitory effect of retinol on lipopolysaccharide-induced target gene expression was still observed in myeloid differentiation primary-response protein 88 (MyD88)- or signal transducer and activator of transcription 1 (STAT1)-deficient macrophages, indicating that MyD88 and STAT1 are dispensable for retinol-mediated blockade of TLRs. Together, the results demonstrate that retinol suppresses the activation of TLRs in macrophages resulting in downregulation of inflammatory gene expression and further suggest that beneficial effect of retinol is mediated through regulation of TLR-mediated inflammatory responses.

Indexed as

AnimalsCells, CulturedEnzyme ActivationGene ExpressionInflammationInterferon-gammaInterleukin-2Interleukin-4LipopolysaccharidesMacrophagesMiceMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88STAT1 Transcription FactorToll-Like Receptor 2Interferon-gammaInterleukin-2Interleukin-4LipopolysaccharidesMyd88 protein, mouseMyeloid Differentiation Factor 88Stat1 protein, mouseSTAT1 Transcription FactorTlr2 protein, mouseTLR3 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 3Toll-Like Receptor 4Toll-Like ReceptorsTumor Necrosis Factor-alphaVitamin AVitamins

Identifiers

PMID23086657
OpenAlexW2041603979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.