ArticleInflammation2013
Antinociceptive effects of radon inhalation on formalin-induced inflammatory pain in mice.
Article in Inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Immunomodulatory Effects of Radon Inhalation on Lipopolysaccharide-Induced Inflammation in Mice.International journal of environmental research and public health · 2022Article
- Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model.Journal of clinical biochemistry and nutrition · 2022Article
- Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy.Journal of clinical biochemistry and nutrition · 2022Article
- Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions.Journal of radiation research · 2021Article
- Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea.Inflammopharmacology · 2021Article
- Radon Exposure-Therapeutic Effect and Cancer Risk.International journal of molecular sciences · 2020Review
- Anti-inflammatory and central and peripheral anti-nociceptive activities of α-asarone through the inhibition of TNF-α production, leukocyte recruitment and iNOS expression, and participation of the adenosinergic and opioidergic systems.Inflammopharmacology · 2020Article
- Study of analgesic effect of earthworm extract.Bioscience reports · 2018Article
- Radon inhalation protects against transient global cerebral ischemic injury in gerbils.Inflammation · 2014Article
- Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation.Journal of radiation research · 2013Review
- Suppression of dextran sulfate sodium-induced colitis in mice by radon inhalation.Mediators of inflammation · 2012Article
- Recovery From Rheumatoid Arthritis Following 15 Months of Therapy With Low Doses of Ionizing Radiation: A Case Report.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radon therapy is clinically useful for the treatment of inflammatory diseases. The mechanisms of pain relief remain to be fully elucidated. In this study, we investigated the antinociceptive effects of radon inhalation in a mouse model of formalin-induced inflammatory pain. Immediately, after radon inhalation at a concentration of background level (ca. 19 Bq/m(3)), 1,000 or 2,000 Bq/m(3) for 24 h, 1.35 % formalin (0.5 % formaldehyde in saline, 20 μl) was subcutaneously injected into the hind paw of mice, and we measured licking response time. Radon inhalation inhibited the second phase of response in formalin test. Formalin administration induced nociception and increased tumor necrosis factor alpha (TNF-α) and nitric oxide (NO) levels in serum and leukocyte migration in paws. Concurrently, formalin injection decreased antioxidative functions. Radon inhalation produced antinociceptive effects, i.e., lowered serum TNF-α and NO levels, and restored antioxidative functions. The results showed that radon inhalation inhibited formalin-induced inflammatory pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.