Evidence map›Paper›PMID 23086591›Full record

ArticlePediatric nephrology (Berlin, Germany)2013

Nutritional vitamin D use in chronic kidney disease: a survey of pediatric nephrologists.

Lindsay M Griffin, Michelle R Denburg, Justine Shults, Susan L Furth, Isidro B Salusky, Wenke Hwang, Mary B Leonard

Open access · greenAbstract read
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Lindsay M GriffinDepartment of Pediatrics, Children's Hospital of Philadelphia, 3535 Market Street, Room 868, Philadelphia, PA, USA.
Michelle R Denburg
Justine Shults
Susan L Furth
Isidro B Salusky
Wenke Hwang
Mary B Leonard
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USPennsylvania State University · USUniversity of California, Los Angeles · US

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
Patient Oriented Research in Vitamin D Deficiency in CKDK24DK076808 · NIDDK · STANFORD UNIVERSITY · PI LEONARD, MARY BETH · 2007 to 2016
$1.7M
Patient Oriented Research in Pediatric Kidney DiseaseK24DK078737 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FURTH, SUSAN L. · 2007 to 2016
$1.6M
Vitamin D Deficiency in Glomerular DiseaseK23DK093556 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI DENBURG, MICHELLE · 2012 to 2016
$858k
NIDDK NIH HHS K23 DK093556NIDDK NIH HHS K24 DK076808NIDDK NIH HHS K24-DK076808NIDDK NIH HHS K24 DK078737NIDDK NIH HHS U01 DK066174
6 · The paper itself

Abstract

backgroundVitamin D deficiency may contribute to risk of cardiovascular disease, diabetes, and infections, in addition to known effects on mineral metabolism. Controversy remains regarding the use of nutritional vitamin D supplementation in chronic kidney disease (CKD), and the supplementation practices of pediatric nephrologists are unknown.

methodsAn electronic survey containing eight vignettes was sent to physician members of the International Pediatric Nephrology Association in 2011 to identify physician and patient characteristics that influence nephrologists to supplement CKD patients with nutritional vitamin D. Vignettes contained patient characteristics including light vs dark skin, CKD stage, cause of renal disease, parathyroid hormone (PTH), and 25(OH) vitamin D levels. Multivariate logistic generalized estimating equation regression was used to identify predictors of supplementation.

resultsOf 1,084 eligible physicians, 504 (46%) completed the survey. Supplementation was recommended in 73% of cases overall (ranging from 91% of those with vitamin D levels <10 ng/mL to 35% with levels >30). Greater CKD severity was associated with greater recommendation of supplementation, especially for patients with higher vitamin D levels (test for interaction p < 0.0001). PTH level above target for CKD stage was associated with greater recommendation to supplement in pre-dialysis CKD, but did not have an impact on recommendations in dialysis patients (test for interaction p < 0.0001). Skin color, cause of CKD, and albumin levels were not associated with supplementation recommendation.

conclusionsRecommending nutritional vitamin D is common worldwide, driven by CKD stage and vitamin D and PTH levels. Future studies are needed to establish the risks and benefits of supplementation.

Indexed as

Dietary SupplementsConfidence IntervalsHumansNephrologyOdds RatioParathyroid HormonePediatricsPractice Guidelines as TopicPractice Patterns, Physicians'Renal Insufficiency, ChronicSeverity of Illness IndexSurveys and QuestionnairesVitamin DVitamin D Deficiency25-hydroxyvitamin DParathyroid HormoneVitamin D

Identifiers

PMID23086591
PMCPMC4052461
OpenAlexW2084129449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.