SynthesisJournal of neurology2013
Central nervous system demyelinating diseases and recombinant hepatitis B vaccination: a critical systematic review of scientific production.
Synthesis in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- HBV vaccine and risk of developing multiple sclerosis: a systematic review and meta-analysis.Human vaccines & immunotherapeutics · 2021Pooled it
- The Role and Safety of Aluminum Adjuvants in Childhood Vaccines.Pediatrics · 2026Review
- Association between vaccination and the risk of central demyelination: results from a case-referent study.Journal of neurology · 2023Article
- Review
- Vaccination in Multiple Sclerosis: Friend or Foe?Frontiers in immunology · 2019Review
- [Multiple sclerosis and hepatitis B vaccination : What does the verdict of the European Court of Justice on liability after vaccination mean?]Der Nervenarzt · 2018Review
- Vaccines in Multiple Sclerosis.Current neurology and neuroscience reports · 2016Review
- Vaccination of Adult Patients with Systemic Lupus Erythematosus in Portugal.International journal of rheumatology · 2016Review
- Prevention of hepatitis B.Cold Spring Harbor perspectives in medicine · 2015Review
- IT Infrastructure to support the secondary use of routinely acquired clinical imaging data for research.Neuroinformatics · 2015Article
- Hepatitis B vaccine adverse events in China: risk control and regulation.Human vaccines & immunotherapeutics · 2014Article
- Applications of nanotechnology for immunology.Nature reviews. Immunology · 2013Review
- Seronegative Neuromyelitis Optica Spectrum Disorder following Exposure to Hepatitis B Vaccination.Case reports in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of multiple sclerosis has not yet been fully described. A potential link between the recombinant hepatitis B vaccine and an increased risk of onset or exacerbation of multiple sclerosis emerged in the mid-1990s, leading to several spontaneous reports and studies investigating this association. We conducted a critical systematic review aimed at assessing whether hepatitis B vaccination increases the risk of onset or relapse of multiple sclerosis and other central nervous system demyelinating diseases. MEDLINE and EMBASE were used as data sources, and the search covered the period between 1981 and 2011. Twelve references met the inclusion criteria. No significant increased risk of onset or relapse of the diseases considered was associated with hepatitis B vaccination, except in one study. Most studies included in this review displayed methodological limitations and heterogeneity among them, which rendered it impossible to draw robust conclusions about the safety of hepatitis B vaccination in healthy subjects and patients with multiple sclerosis. Therefore, on the basis of current data there is no need to modify the vaccination recommendations; however, there is a need to improve the quality of observational studies with emphasis on certain considerations that are discussed in this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.