Evidence map›Paper›PMID 23086116›Full record

ArticleDigestive diseases and sciences2013

Insulin sensitivity and variability in hepatitis C virus infection using direct measurement.

Nizar A Mukhtar, Peter Bacchetti, Claudia E Ayala, Jennifer Melgar, Spencer Christensen, Jacquelyn J Maher, Mandana Khalili

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01858012 (Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in Latinos), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01858012 active not recruitingnot on this map

Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in Latinos

TypeobservationalSponsorUniversity of California, San FranciscoRan2008 to 2026Enrolled250ConditionsInsulin ResistanceArmsModerate alcohol cessation
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Hepatitis C Virus, Insulin Resistance, and Steatosis.Journal of clinical and translational hepatology · 2016
    Review
  7. Article
  8. Observational
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nizar A MukhtarDepartment of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Peter Bacchetti
Claudia E Ayala
Jennifer Melgar
Spencer Christensen
Jacquelyn J Maher
Mandana Khalili
San Francisco General Hospital · USUniversity of California, San Francisco · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
WELFARE REFORM AND THE PERINATAL HEALTH OF IMMIGRANTSM01RR000083 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$21.1M
Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in LatinosR01DK074673 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2008 to 2012
$2.2M
NCRR NIH HHS M01 RR000083NCRR NIH HHS UL1 RR024131NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK026743NIDDK NIH HHS R01 DK074673
6 · The paper itself

Abstract

BACKGROUND AND

aimsStudies investigating insulin resistance (IR) in chronic hepatitis C virus (HCV) infection have used surrogate measures of IR that have limited reliability. We aimed to describe the distribution and risk factors associated with IR and its change over time in HCV using direct measurement.

methodsOne hundred two non-cirrhotic, non-diabetic, HCV-infected subjects underwent clinical, histologic, and metabolic evaluation, and 27 completed repeat evaluation at 6 months. Insulin-mediated glucose uptake was measured by steady-state plasma glucose (SSPG) concentration during the insulin suppression test.

resultsThree subjects with diabetes were excluded and 95 completed all testing. SSPG ranged from 39 to 328 mg/dL (mean 135 mg/dL) and was stable over time (mean SSPG change -0.3 mg/dL). SSPG was associated with Latino ethnicity (Coef 67, 95 % CI 37-96), BMI (Coef 19 per 5 kg/m(2), 95 % CI 5-32), ferritin (Coef 1.4 per 10 ng/ml, 95 % CI 0.2-2.5), male gender (Coef -48, 95 % CI -80 to -16), and HDL (Coef -16, 95 % CI -28 to -5 mg/dL). Current tobacco use (Coef 55, 95 % CI 19-90), steatosis (Coef -44, 95 % CI -86 to -3), and increases in BMI (Coef 30 per 5 kg/m(2), 95 % CI 6-53) and triglyceride (Coef 3.5 per 10 mg/dL, 95 % CI 0.3-6.7) predicted change in SSPG.

conclusionsThere was a wide spectrum of insulin resistance in our HCV population. Host factors, rather than viral factors, appeared to more greatly influence insulin action and its change in HCV.

Indexed as

Insulin ResistanceAdultBlood GlucoseFemaleHepatitis C, ChronicHumansMaleMiddle AgedProspective StudiesBlood Glucose

Identifiers

PMID23086116
PMCPMC3566265
OpenAlexW1980312510

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.