ArticleThe Plant cell2012
Spatio-temporal cellular dynamics of the Arabidopsis flagellin receptor reveal activation status-dependent endosomal sorting.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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Who cites it
131 citing papers in PubMed, 267 citations in OpenAlex.
- Synthetic FLS2 receptor oligomer boosts plant innate immunity.Science advances · 2026Article
- The ubiquitin code of receptor kinases in plants.Journal of integrative plant biology · 2026Review
- Shigella Effector VirA Suppresses Plant Immunity by Compromising PRA1.F3-Dependent Accumulation of FLS2 at the Plasma Membrane.Plant, cell & environment · 2026Article
- Lavandin cell extract enriched in rosmarinic acid attenuates inflammation via AMPK/Nrf2/HO-1 activation and IKK/IκB/NF-κB inhibition.BMC plant biology · 2026Article
- The E3 ubiquitin ligases ATL31/6 mediate TMK1 degradation to downregulate TMK1-dependent auxin signaling in Arabidopsis.Plant communications · 2026Article
- Cytoskeletal control of development and environmental adaptation in plants.Science China. Life sciences · 2026Review
- Ubiquitination of BAM1 attenuates CLE peptide-mediated signaling in the root apical meristem.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dynamics of full-length Arabidopsis myosin XI and its involvement in actin remodeling.Plant & cell physiology · 2025Article
- Flagellin sensing, signaling, and immune responses in plants.Plant communications · 2025Review
- A plant Lysin Motif Receptor-Like Kinase plays an ancestral function in mycorrhiza.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- ZmGCT1/2 negatively regulate drought tolerance in maize by inhibiting ZmSLAC1 to maintain guard cell turgor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of Exo70s in plant defense against pathogens and insect pests and their application for crop breeding.Molecular breeding : new strategies in plant improvement · 2025Review
- The leucine-rich repeat receptor kinase QSK1 regulates PRR-RBOHD complexes targeted by the bacterial effector HopF2Pto.The Plant cell · 2024Article
- Emerging Roles of Exocyst Complex in Fungi: A Review.Journal of fungi (Basel, Switzerland) · 2024Review
- Myosin XI-mediated BIK1 recruitment to nanodomains facilitates FLS2-BIK1 complex formation during innate immunity inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Logistics of defense: The contribution of endomembranes to plant innate immunity.The Journal of cell biology · 2024Review
- Insights into the Mechanism of Action of the Degraded Limonoid Prieurianin.International journal of molecular sciences · 2024Review
- The damage-associated molecular pattern cellotriose alters the phosphorylation pattern of proteins involved in cellulose synthesis andPlant signaling & behavior · 2023Article
- NET4 and RabG3 link actin to the tonoplast and facilitate cytoskeletal remodelling during stomatal immunity.Nature communications · 2023Article
- TPLATE complex-dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance.EMBO reports · 2023Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activity of surface receptors is location specific, dependent upon the dynamic membrane trafficking network and receptor-mediated endocytosis (RME). Therefore, the spatio-temporal dynamics of RME are critical to receptor function. The plasma membrane receptor flagellin sensing2 (FLS2) confers immunity against bacterial infection through perception of flagellin (flg22). Following elicitation, FLS2 is internalized into vesicles. To resolve FLS2 trafficking, we exploited quantitative confocal imaging for colocalization studies and chemical interference. FLS2 localizes to bona fide endosomes via two distinct endocytic trafficking routes depending on its activation status. FLS2 receptors constitutively recycle in a Brefeldin A (BFA)-sensitive manner, while flg22-activated receptors traffic via ARA7/Rab F2b- and ARA6/Rab F1-positive endosomes insensitive to BFA. FLS2 endocytosis required a functional Rab5 GTPase pathway as revealed by dominant-negative ARA7/Rab F2b. Flg22-induced FLS2 endosomal numbers were increased by Concanamycin A treatment but reduced by Wortmannin, indicating that activated FLS2 receptors are targeted to late endosomes. RME inhibitors Tyrphostin A23 and Endosidin 1 altered but did not block induced FLS2 endocytosis. Additional inhibitor studies imply the involvement of the actin-myosin system in FLS2 internalization and trafficking. Altogether, we report a dynamic pattern of subcellular trafficking for FLS2 and reveal a defined framework for ligand-dependent endocytosis of this receptor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.