ArticleGastroenterology2013
Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice.
Article in Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- OBSERVE: guidelines for the refinement of rodent cancer models.Nature protocols · 2024Review
- Expression of periostin according to endometrial cancer grade.Oncology letters · 2022Article
- Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.Gastroenterology · 2018Review
- Prognostic Significance of Periostin and Mammalian Target of Rapamycin (mTOR) in Locally Advanced Esophageal Squamous Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- A panel of autoantibodies against multiple tumor-associated antigens in the immunodiagnosis of esophageal squamous cell cancer.Cancer immunology, immunotherapy : CII · 2016Article
- Coexpression of periostin and EGFR in patients with esophageal squamous cell carcinoma and their prognostic significance.OncoTargets and therapy · 2016Article
- Imaging of Secreted Extracellular Periostin, an Important Marker of Invasion in the Tumor Microenvironment in Esophageal Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
- Periostin expression and its prognostic value for colorectal cancer.International journal of molecular sciences · 2015Article
- WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma.Carcinogenesis · 2015Article
- Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications.Experimental and molecular pathology · 2014Review
- Molecular imaging in gastroenterology.Nature reviews. Gastroenterology & hepatology · 2013Review
- Endoscopic molecular imaging of cancer.Future oncology (London, England) · 2013Review
- Research advances in esophageal diseases: bench to bedside.F1000prime reports · 2013Review
- Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment.Oncogenesis · 2013Article
- Matricellular proteins: priming the tumour microenvironment for cancer development and metastasis.British journal of cancer · 2013Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Imaging strategies that detect early stage esophageal squamous cell carcinoma (ESCC) could improve clinical outcomes, when combined with endoscopic approaches. Periostin is an integrin-binding protein that is important in the tumor microenvironment. We created a fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumors in mice. In L2-cre;p120ctnLoxP/LoxP mice, which develop squamous cell cancers that resemble human ESCC, we visualized the probe in preneoplastic and neoplastic esophageal lesions using near-infrared fluorescent imaging with upper-gastrointestinal endoscopy. Periostin might be a biomarker of the esophageal tumor microenvironment that can be used to detect preneoplastic lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.