ArticleBehavioural brain research2013
Impulsive choice behavior in four strains of rats: evaluation of possible models of Attention-Deficit/Hyperactivity Disorder.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- The Wistar-Kyoto rat as a model relevant to inattentive ADHD: substrain variability and affective comorbidity.Pharmacological reports : PR · 2026Review
- Using rodent data to elucidate dopaminergic mechanisms of ADHD: Implications for human personality.Personality neuroscience · 2024Review
- Previous experience with delays affects delay discounting in animal model of ADHD.Behavioral and brain functions : BBF · 2023Article
- Impulsive choice in two different rat models of ADHD-Spontaneously hypertensive andFrontiers in neuroscience · 2023Article
- Animal Models of ADHD?Current topics in behavioral neurosciences · 2022Article
- Article
- Differential effects of d-amphetamine and atomoxetine on risk-based decision making of Lewis and Fischer 344 rats.Behavioural pharmacology · 2019Article
- Linking Delay Discounting and Substance Use Disorders: Genotypes and Phenotypes.Perspectives on behavior science · 2019Article
- Article
- Effect of Schedule-Induced Behavior on Responses of Spontaneously Hypertensive and Wistar-Kyoto Rats in a Delay-Discounting Task: A Preliminary Report.Frontiers in behavioral neuroscience · 2019Article
- Pair Housing Alters Delay Discounting in Lewis and Fischer 344 Rats.The Psychological record · 2018Article
- Logical fallacies in animal model research.Behavioral and brain functions : BBF · 2017Review
- Mechanisms of impulsive choice: III. The role of reward processes.Behavioural processes · 2016Article
- Continuous Aerobic Training in Individualized Intensity Avoids Spontaneous Physical Activity Decline and Improves MCT1 Expression in Oxidative Muscle of Swimming Rats.Frontiers in physiology · 2016Article
- Reward Contrast Effects on Impulsive Choice and Timing in Rats.Timing & time perception (Leiden, Netherlands) · 2016Article
- Mechanisms of impulsive choice: II. Time-based interventions to improve self-control.Behavioural processes · 2015Article
- Measurement of impulsive choice in rats: same- and alternate-form test-retest reliability and temporal tracking.Journal of the experimental analysis of behavior · 2015Article
- Article
- Everywhere and everything: The power and ubiquity of time.International journal of comparative psychology · 2015Article
- I can't wait: Methods for measuring and moderating individual differences in impulsive choice.Journal of agricultural & food industrial organization · 2015Article
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2 authors.
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Abstract
Several studies have examined impulsive choice behavior in spontaneously hypertensive rats (SHRs) as a possible pre-clinical model for Attention-Deficit/Hyperactivity Disorder (ADHD). However, this strain was not specifically selected for the traits of ADHD and as a result their appropriateness as a model has been questioned. The present study investigated whether SHRs would exhibit impulsive behavior in comparison to their control strain, Wistar Kyoto (WKY) rats. In addition, we evaluated a strain that has previously shown high levels of impulsive choice, the Lewis (LEW) rats and compared them with their source strain, Wistar (WIS) rats. In the first phase, rats could choose between a smaller-sooner (SS) reward of 1 pellet after 10 s and a larger-later (LL) reward of 2 pellets after 30 s. Subsequently, the rats were exposed to increases in LL reward magnitude and SS delay. These manipulations were designed to assess sensitivity to magnitude and delay within the choice task to parse out possible differences in using the strains as models of specific deficits associated with ADHD. The SHR and WKY strains did not differ in their choice behavior under either delay or magnitude manipulations. In comparison to WIS, LEW showed deficits in choice behavior in the delay manipulation, and to a lesser extent in the magnitude manipulation. An examination of individual differences indicated that the SHR strain may not be sufficiently homogeneous in their impulsive choice behavior to be considered as a viable model for impulse control disorders such as ADHD. The LEW strain may be worthy of further consideration for their suitability as an animal model.
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