ArticleBehavioural brain research2013
Alterations in expression and phosphorylation of GluA1 receptors following cocaine-cue extinction learning.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Targeting VMPFC-amygdala circuit with TMS in substance use disorder: A mechanistic framework.Addiction biology · 2025Article
- Molecular mechanisms underlying sex and treatment-dependent differences in an animal model of cue-exposure therapy for cocaine relapse prevention.Frontiers in neuroscience · 2024Article
- A limited and intermittent access to a high-fat diet modulates the effects of cocaine-induced reinstatement in the conditioned place preference in male and female mice.Psychopharmacology · 2021Article
- Molecular and circuit mechanisms regulating cocaine memory.Cellular and molecular life sciences : CMLS · 2020Review
- Facilitative effects of environmental enrichment for cocaine relapse prevention are dependent on extinction training context and involve increased TrkB signaling in dorsal hippocampus and ventromedial prefrontal cortex.Behavioural brain research · 2020Article
- Glutamate receptor interacting protein acts within the prefrontal cortex to blunt cocaine seeking.Neuropharmacology · 2019Article
- Extinction of Contextual Cocaine Memories Requires CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation.Addiction biology · 2017Article
- Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits.Neural plasticity · 2016Article
- Role of the ventral tegmental area in methamphetamine extinction: AMPA receptor-mediated neuroplasticity.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Bidirectional effects of inhibiting or potentiating NMDA receptors on extinction after cocaine self-administration in rats.Psychopharmacology · 2014Article
- Cortico-amygdala coupling as a marker of early relapse risk in cocaine-addicted individuals.Frontiers in psychiatry · 2014Article
- The Plasticity of Extinction: Contribution of the Prefrontal Cortex in Treating Addiction through Inhibitory Learning.Frontiers in psychiatry · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Brain regional analyses of total GluA1 and GluA1-pSer(845) were used to delineate plasticity of the AMPA receptor in conjunction with cocaine-cue extinction learning. Rats were trained to self-administer cocaine paired with a 2-s light cue and later underwent a single 2 h extinction session for which cocaine was withheld but response-contingent cues were presented. Control groups received yoked-saline sessions or received cocaine self-administration training without undergoing extinction training. Extinction-related increases and decreases, respectively, in total GluA1 were observed in the ventromedial prefrontal cortex (vmPFC) and basolateral amygdala (BLA). Phosphorylation of GluA1 at Ser(845) was increased in the vmPFC and nucleus accumbens (NAc). Though total GluA1 did not change in NAc, there was a positive association between the number of responses during extinction training and the magnitude of total GluA1 in NAc. No significant changes were evident in the dorsal hippocampus. We conclude that the BLA and vmPFC, in particular, appear to be loci for the inhibition of learned behavior induced via extinction training, but each site may have different signaling functions for cocaine-cue extinction learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.