Evidence map›Paper›PMID 23085399›Full record

ReviewPhysiology & behavior2014

Maternal high fat diet consumption during the perinatal period programs offspring behavior.

Elinor L Sullivan, Elizabeth K Nousen, Katherine A Chamlou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 5 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 5 syntheses or guidelines pooled it, 216 citations in OpenAlex.

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  10. The Evolving ADHD Phenotype in the Externalizing Context.The American journal of psychiatry · 2026
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Elinor L SullivanDepartment of Biology, University of Portland, Portland, OR, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA. Electronic address: sullivae@up.edu.
Elizabeth K Nousen
Katherine A Chamlou
University of Portland · US

Funding

YR 50 PROJ- ROBERTS PRIMATE ISLETP51RR000163 · NCRR · OREGON REGIONAL PRIMATE RESEARCH CENTER · PI FRUH, KLAUS J · 1985 to 2011
$140.8M
Maternal High Fat Diet and Melanocortin System in OffspringR01DK079194 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KIEVIT, PAUL · 2007 to 2015
$6.2M
NCRR NIH HHS P51 RR000163NICHD NIH HHS L40 HD059242NIDDK NIH HHS R01 DK079194
6 · The paper itself

Abstract

The environment that a developing offspring experiences during the perinatal period is markedly influenced by maternal health and diet composition. Evidence from both epidemiological studies and animal models indicates that maternal diet and metabolic status play a critical role in programming the neural circuitry that regulates behavior, resulting in long-term consequences for offspring behavior. Maternal diet and metabolic state influence the behavior of offspring directly by impacting the intrauterine environment and indirectly by modulating maternal behavior. The mechanisms by which maternal diet and metabolic profile shape the perinatal environment remain largely unknown, but recent research has found that increases in inflammatory cytokines, nutrients (glucose and fatty acids), and hormones (insulin and leptin) affect the environment of the developing offspring. Offspring exposed to maternal obesity and high fat diet consumption during development are more susceptible to developing mental health and behavioral disorders such as anxiety, depression, attention deficit hyperactivity disorder, and autism spectrum disorders. Recent evidence suggests that this increased risk for behavioral disorders is driven by modifications in the development of neural pathways involved in behavioral regulation. In particular, research indicates that the development of the serotonergic system is impacted by exposure to maternal obesity and high fat diet consumption, and this disruption may underlie many of the behavioral disturbances observed in these offspring. Given the high rates of obesity and high fat diet consumption in pregnant women, it is vital to examine the influence that maternal nutrition and metabolic profile have on the developing offspring.

Indexed as

Child Behavior DisordersChild, PreschoolDiet, High-FatFemaleHumansMaternal Nutritional Physiological PhenomenaPregnancyPrenatal Exposure Delayed EffectsAnxietyAttention deficit hyperactivity disorderAutism spectrum disordersDepressionInflammationMaternal high fat dietObesity

Identifiers

PMID23085399
PMCPMC3594403
OpenAlexW2050705896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.