ArticleExperimental and molecular pathology2013
MicroRNAs in HIV-associated nephropathy (HIVAN).
Article in Experimental and molecular pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Article
- Detection of microRNA-33a-5p in serum, urine and renal tissue of patients with IgA nephropathy.Experimental and therapeutic medicine · 2021Article
- MicroRNAs and exosomes: key players in HIV pathogenesis.HIV medicine · 2020Review
- Hedgehog pathway plays a vital role in HIV-induced epithelial-mesenchymal transition of podocyte.Experimental cell research · 2017Article
- HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment.Nature reviews. Nephrology · 2015Review
- Association of miR-146a rs2910164 with childhood IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2014Article
- MicroRNA roles in the NF- κB signaling pathway during viral infections.BioMed research international · 2014Review
- Bone-derived mesenchymal stromal cells from HIV transgenic mice exhibit altered proliferation, differentiation capacity and paracrine functions along with impaired therapeutic potential in kidney injury.Experimental cell research · 2013Article
- Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN).Experimental cell research · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs (miRNAs) play a critical role in multiple biological and metabolic processes. Recent studies suggested that miRNAs are critical in the maintenance of glomerular homeostasis in both physiological and pathological states. However, the role of miRNAs in the pathogenesis of HIV-associated nephropathy (HIVAN) has not been studied. In the present study, we have used a microarray-based approach in combination with real-time PCR to profile the miRNA expression patterns in HIV-1 transgenic mice (Tg26). Our results showed that 13 miRNAs, which belong to 11 miRNA families, were downregulated in HIVAN when compared with control mice. These miRNAs were classified into 20 functional categories. In in vitro studies, we examined the expression of specific miRNAs in HIV-1 transduced human podocytes. Our results showed that HIV-1 downregulated miRNA expression, specifically of miR-200 and miR-33. These studies suggest that miRNAs contributed to the development of the proliferative phenotype of HIVAN. Further functional analysis of these miRNAs in HIVAN animal model will not only enhance understanding of the pathogenesis but would also lead to the development of therapeutic strategies for HIVAN patients.
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