ArticleNeuroImage2013
White-matter diffusion fMRI of mouse optic nerve.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Characterising the Diffusion Functional Signature of Negative BOLD With Interleaved TMS-fMRI in the Human Brain.Human brain mapping · 2026Article
- Complementarity of BOLD and ADC-fMRI in Mapping Brain Visual Processing in the Rat.NMR in biomedicine · 2026Article
- Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI.Nature communications · 2025Article
- Apparent Diffusion Coefficient fMRI shines light on white matter resting-state connectivity compared to BOLD.Communications biology · 2025Article
- Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain.Human brain mapping · 2025Article
- Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Evaluating the dependence of ADC-fMRI on haemodynamics in breath-hold and resting-state conditions.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Whole-brain, gray, and white matter time-locked functional signal changes with simple tasks and model-free analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Detection of functional activity in brain white matter using fiber architecture informed synchrony mapping.NeuroImage · 2022Article
- The present and the future of microstructure MRI: From a paradigm shift to normal science.Journal of neuroscience methods · 2021Review
- Diffusion Basis Spectrum Imaging Detects Axonal Loss After Transient Dexamethasone Treatment in Optic Neuritis Mice.Frontiers in neuroscience · 2020Article
- On the Origins of Diffusion MRI Signal Changes in Stroke.Frontiers in neurology · 2020Article
- Layer-specific connectivity revealed by diffusion-weighted functional MRI in the rat thalamocortical pathway.NeuroImage · 2019Article
- MRI-based assessment of function and dysfunction in myelinated axons.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity.Brain structure & function · 2018Article
- Mapping white-matter functional organization at rest and during naturalistic visual perception.NeuroImage · 2017Article
- Long-term effects of neonatal hypoxia-ischemia on structural and physiological integrity of the eye and visual pathway by multimodal MRI.Investigative ophthalmology & visual science · 2014Article
- Phase-aligned multiple spin-echo averaging: a simple way to improve signal-to-noise ratio of in vivo mouse spinal cord diffusion tensor image.Magnetic resonance imaging · 2014Article
- Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis.Neurobiology of disease · 2014Article
- Manganese-enhanced MRI (MEMRI) via topical loading of Mn(2+) significantly impairs mouse visual acuity: a comparison with intravitreal injection.NMR in biomedicine · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Non-invasive assessment of white-matter functionality in the nervous system would be a valuable basic neuroscience and clinical diagnostic tool. Using standard MRI techniques, a visual-stimulus-induced 27% decrease in the apparent diffusion coefficient of water perpendicular to the axonal fibers (ADC(perpendicular)) is demonstrated for C57BL/6 mouse optic nerve in vivo. No change in ADC(||) (diffusion parallel to the optic nerve fibers) was observed during visual stimulation. The stimulus-induced changes are completely reversible. A possible vascular contribution was sought by carrying out the ADC(perpendicular) measurements in hypercapnic mice with and without visual stimulus. Similar effects were seen in room-air-breathing and hypercapnic animals. The in vivo stimulus-induced ADC(perpendicular) decreases are roughly similar to literature reports for ex vivo rat optic nerve preparations under conditions of osmotic swelling. The experimental results strongly suggest that osmotic after-effects of nerve impulses through the axonal fibers are responsible for the observed ADC decrease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.