ArticleToxicology and applied pharmacology2012
Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia.
Article in Toxicology and applied pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed.
- Assessment of toxicity changes induced by exposure of human cells to lunar dust simulant.Scientific reports · 2024Article
- Promotion of myofibroblast differentiation through repeated treatment of fibroblasts to low concentrations of PMEnvironmental toxicology and pharmacology · 2024Article
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter.Scientific reports · 2022Article
- Systems level insights into the impact of airborne exposure on SARS-CoV-2 pathogenesis and COVID-19 outcome - A multi-omics big data study.Gene reports · 2021Article
- Transcriptomic analysis of key genes and pathways in human bronchial epithelial cells BEAS-2B exposed to urban particulate matter.Environmental science and pollution research international · 2021Article
- Effect of concentration and duration of particulate matter exposure on the transcriptome and DNA methylome of bronchial epithelial cells.Environmental epigenetics · 2021Article
- IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis.International journal of molecular sciences · 2020Article
- A novel water-in-oil emulsion with a lecithin-modified bentonite prevents skin damage from urban dust and cedar pollen.International journal of cosmetic science · 2020Article
- Association of Long-term Exposure to Ambient Air Pollutants With Risk Factors for Cardiovascular Disease in China.JAMA network open · 2019Article
- Interface effect of natural precipitated dust on the normal flora of Escherichia coli and Staphylococcus epidermidis.Environmental science and pollution research international · 2018Article
- Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles.BMC genomics · 2018Article
- Effects of ambient PMToxicology research · 2017Article
- Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches.International journal of environmental research and public health · 2017Article
- Predictive and Prognostic Biomarkers of Respiratory Diseases due to Particulate Matter Exposure.Journal of cancer prevention · 2017Review
- Association between sleeping hours and cardiometabolic risk factors for metabolic syndrome in a Saudi Arabian population.BMJ open · 2015Article
- In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.Journal of toxicology and environmental health. Part A · 2015Article
- Arsenic induces polyadenylation of canonical histone mRNA by down-regulating stem-loop-binding protein gene expression.The Journal of biological chemistry · 2014Article
- Particulate matter from Saudi Arabia induces genes involved in inflammation, metabolic syndrome and atherosclerosis.Journal of toxicology and environmental health. Part A · 2014Article
- Signal transduction disturbance related to hepatocarcinogenesis in mouse by prolonged exposure to Nanjing drinking water.Environmental science and pollution research international · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Epidemiological studies have established a positive correlation between human mortality and increased concentration of airborne particulate matters (PM). However, the mechanisms underlying PM related human diseases, as well as the molecules and pathways mediating the cellular response to PM, are not fully understood. This study aims to investigate the global gene expression changes in human cells exposed to PM(10) and to identify genes and pathways that may contribute to PM related adverse health effects. Human bronchial epithelial cells were exposed to PM(10) collected from Saudi Arabia for 1 or 4 days, and whole transcript expression was profiled using the GeneChip human gene 1.0 ST array. A total of 140 and 230 genes were identified that significantly changed more than 1.5 fold after PM(10) exposure for 1 or 4 days, respectively. Ingenuity Pathway Analysis revealed that different exposure durations triggered distinct pathways. Genes involved in NRF2-mediated response to oxidative stress were up-regulated after 1 day exposure. In contrast, cells exposed for 4 days exhibited significant changes in genes related to cholesterol and lipid synthesis pathways. These observed changes in cellular oxidative stress and lipid synthesis might contribute to PM related respiratory and cardiovascular disease.
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Registered trials
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