ArticleCurrent biology : CB2012
Organelle size equalization by a constitutive process.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Distinct disassembly modes shape cytoskeletal assembly and fluctuations.Biophysical reports · 2026Article
- Quantitative Signatures of Disassembly Mechanisms Modulating Filament and Bundle Assembly in a Shared Pool.bioRxiv : the preprint server for biology · 2025Article
- Design principles and feedback mechanisms in organelle size control.Current opinion in cell biology · 2025Review
- Seeing with an extra sense.Current biology : CB · 2024Article
- Limiting pool and actin architecture controls myosin cluster sizes in adherent cells.Biophysical journal · 2024Article
- Review
- The flagellar length control system: exploring the physical biology of organelle size.Physical biology · 2023Review
- Emergence and maintenance of variable-length actin filaments in a limiting pool of building blocks.Biophysical journal · 2022Article
- Size regulation of multiple organelles competing for a limiting subunit pool.PLoS computational biology · 2022Article
- Article
- Global asymptotic stability of the active disassembly model of flagellar length control.Journal of mathematical biology · 2021Article
- Article
- Scaling of Subcellular Structures.Annual review of cell and developmental biology · 2020Review
- Testing the role of intraflagellar transport in flagellar length control using length-altering mutants ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Length regulation of multiple flagella that self-assemble from a shared pool of components.eLife · 2019Article
- Myosin-independent cytokinesis inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Self-repairing cells: How single cells heal membrane ruptures and restore lost structures.Science (New York, N.Y.) · 2017Review
- Protein transport in growing and steady-state cilia.Traffic (Copenhagen, Denmark) · 2017Review
- Intraflagellar Transport and Ciliary Dynamics.Cold Spring Harbor perspectives in biology · 2017Review
- Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.Development (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
How cells control organelle size is an elusive problem. Two predominant models for size control can be distinguished: (1) induced control, where organelle genesis, maintenance, and disassembly are three separate programs that are activated in response to size change, and (2) constitutive control, where stable size results from the balance between continuous organelle assembly and disassembly. The problem has been studied in Chlamydomonas reinhardtii because the flagella are easy to measure, their size changes only in the length dimension, and the genetics are comparable to yeast. Length dynamics in Chlamydomonas flagella are quite robust: they maintain a length of about 12 μm and recover from amputation in about 90 min with a growth rate that decreases smoothly to zero as the length approaches 12 μm. Despite a wealth of experimental studies, existing data are consistent with both induced and constitutive control models for flagella. Here we developed novel microfluidic trapping and laser microsurgery techniques in Chlamydomonas to distinguish between length control models by measuring the two flagella on a single cell as they equilibrate after amputation of a single flagellum. The results suggest that cells equalize flagellar length by constitutive control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.