ArticleCell host & microbe2012
Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila.
Article in Cell host & microbe, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 64 citations in OpenAlex.
- Tissue specific innate immune responses impact viral infection in Drosophila.PLoS pathogens · 2024Article
- Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2'3'-cGAMP Responses.Molecular biology and evolution · 2024Article
- Wolbachia-mediated resistance to Zika virus infection in Aedes aegypti is dominated by diverse transcriptional regulation and weak evolutionary pressures.PLoS neglected tropical diseases · 2023Article
- Article
- Elucidating the role of dsRNA sensing and Toll6 in antiviral responses ofFrontiers in cellular and infection microbiology · 2023Article
- The DEAD-box RNA helicase Dhx15 controls glycolysis and arbovirus replication in Aedes aegypti mosquito cells.PLoS pathogens · 2022Article
- Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes.Cell reports · 2021Article
- MHC Class III RNA Binding Proteins and Immunity.RNA biology · 2021Review
- Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia.Oncoimmunology · 2021Article
- Sending Out Alarms: A Perspective on Intercellular Communications in Insect Antiviral Immune Response.Frontiers in immunology · 2021Review
- Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.Frontiers in genetics · 2020Article
- Artificial Selection Finds New Hypotheses for the Mechanism ofFrontiers in microbiology · 2020Article
- Article
- Hexamethylene bisacetamide impairs NK cell-mediated clearance of acute T lymphoblastic leukemia cells and HIV-1-infected T cells that exit viral latency.Scientific reports · 2019Article
- The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.Immunity · 2018Article
- Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain.Cell host & microbe · 2018Article
- Defense Mechanisms against Viral Infection inViruses · 2018Review
- Review
- Innate and intrinsic antiviral immunity in Drosophila.Cellular and molecular life sciences : CMLS · 2017Review
- Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Innate immune responses are characterized by precise gene expression whereby gene subsets are temporally induced to limit infection, although the mechanisms involved are incompletely understood. We show that antiviral immunity in Drosophila requires the transcriptional pausing pathway, including negative elongation factor (NELF) that pauses RNA polymerase II (Pol II) and positive elongation factor b (P-TEFb), which releases paused Pol II to produce full-length transcripts. We identify a set of genes that is rapidly transcribed upon arbovirus infection, including components of antiviral pathways (RNA silencing, autophagy, JAK/STAT, Toll, and Imd) and various Toll receptors. Many of these genes require P-TEFb for expression and exhibit pausing-associated chromatin features. Furthermore, transcriptional pausing is critical for antiviral immunity in insects because NELF and P-TEFb are required to restrict viral replication in adult flies and vector mosquito cells. Thus, transcriptional pausing primes virally induced genes to facilitate rapid gene induction and robust antiviral responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.