Evidence map›Paper›PMID 23084914›Full record

ReviewCell host & microbe2012

Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine.

Elia D Tait Wojno, David Artis

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Review
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elia D Tait WojnoDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. eliadta@mail.med.upenn.edu
David Artis

Funding

Regulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0M
Innate immunity and inflammation following helminth infectionR01AI074878 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2008 to 2019
$4.2M
Immuno-regulation of GI nematode infectionR01AI061570 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2004 to 2013
$4.1M
Regulation and function of innate lymphoid cells in the gutR01AI095466 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2011 to 2022
$3.7M
Regulation and function of innate lymphoid cells during influenza virus infectionR01AI102942 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2013 to 2017
$2.1M
Cytokine regulation of anti-helminth immunityR01AI097333 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2012 to 2016
$2.0M
Training in bacteriologyT32AI060516 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D, ZHU, JUN · 2006 to 2015
$2.0M
Functional Biology of Intestinal Epithelial Cells in Food AllergyR21AI087990 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ARTIS, DAVID, ZIEGLER, STEVEN F · 2010 to 2011
$484k
Epithelial cell regulation of intestinal immune homeostasisR21AI083480 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ARTIS, DAVID · 2009 to 2010
$436k
Cytokine regulation of human basophil responsesF32AI098365 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TAIT WOJNO, ELIA D · 2012 to 2013
$101k
NIAID NIH HHS AI061570NIAID NIH HHS AI074878NIAID NIH HHS AI083480NIAID NIH HHS AI087990NIAID NIH HHS AI095466NIAID NIH HHS AI095608NIAID NIH HHS AI097333NIAID NIH HHS F32 AI098365NIAID NIH HHS F32-AI098365NIAID NIH HHS R01 AI061570NIAID NIH HHS R01 AI074878NIAID NIH HHS R01 AI095466NIAID NIH HHS R01 AI097333NIAID NIH HHS R01 AI102942NIAID NIH HHS R21 AI083480NIAID NIH HHS R21 AI087990NIAID NIH HHS T32 AI060516NIAID NIH HHS T32-AI060516NIAID NIH HHS U01 AI095608
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a recently described group of innate immune cells that can regulate immunity, inflammation, and tissue repair in multiple anatomical compartments, particularly the barrier surfaces of the skin, airways, and intestine. Broad categories of ILCs have been defined based on transcription factor expression and the ability to produce distinct patterns of effector molecules. Recent studies have revealed that ILC populations can regulate commensal bacterial communities, contribute to resistance to helminth and bacterial pathogens, promote inflammation, and orchestrate tissue repair and wound healing. This review will examine the phenotype and function of murine and human ILCs and discuss the critical roles these innate immune cells play in health and disease.

Indexed as

Immunity, InnateAnimalsDisease Models, AnimalEnteritisHumansLymphocytesMice

Identifiers

PMID23084914
PMCPMC3584448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.