Evidence map›Paper›PMID 23084873›Full record

ReviewAdvances in genetics2012

Precision editing of large animal genomes.

Wenfang Spring Tan, Daniel F Carlson, Mark W Walton, Scott C Fahrenkrug, Perry B Hackett

Abstract readReview
In one paragraph

Review in Advances in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. Review
  3. Targeted Gene Editing in Porcine Germ Cells.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Review
  5. Review
  6. Genome Editing in Livestock, Complicity, and the Technological Fix Objection.Journal of agricultural & environmental ethics · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. DNA Transposition at Work.Chemical reviews · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wenfang Spring TanCenter for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
Daniel F Carlson
Mark W Walton
Scott C Fahrenkrug
Perry B Hackett
University of Minnesota · US

Funding

THERAPY FOR HYPERAMMONEMIA WITH GENETICALLY ENGINEERED BACTERIAP01HD032652 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WHITLEY, CHESTER B. · 1995 to 2016
$14.5M
SB Transposons for Gene TherapyR01DK082516 · NIDDK · UNIVERSITY OF MINNESOTA · PI HACKETT, PERRY B. · 2010 to 2013
$1.3M
Development of Porcine Genetic Models of AtherosclerosisR41HL108440 · NHLBI · RECOMBINETICS, INC. · PI FAHRENKRUG, SCOTT CHRISTOPHER · 2011 to 2011
$318k
NCRR NIH HHS 1R43 RR033149NHLBI NIH HHS 1R41HL108440NHLBI NIH HHS R41 HL108440NICHD NIH HHS P01 HD032652NICHD NIH HHS P01HD32652NIDDK NIH HHS 1R01DK082516NIDDK NIH HHS R01 DK082516
6 · The paper itself

Abstract

Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.

Indexed as

Disease Models, AnimalGenetic EngineeringMeatAnimalsAnimals, DomesticAnimals, Genetically ModifiedFood SupplyGenomeHumans

Identifiers

PMID23084873
PMCPMC3683964
OpenAlexW1776589336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.