ArticleBiosensors & bioelectronics2013
Parallel recording of neurotransmitters release from chromaffin cells using a 10×10 CMOS IC potentiostat array with on-chip working electrodes.
Article in Biosensors & bioelectronics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A Dual-Mode Neural Amplifier Array for Biopotential and FSCV-Based Neurochemical Measurements.Biosensors · 2026Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- A 512-Ch Dual-Mode Microchip for Simultaneous Measurements of Electrophysiological and Neurochemical Activities.Biosensors · 2023Article
- Methodologies for Detecting Quantal Exocytosis in Adrenal Chromaffin Cells Through Diamond-Based MEAs.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells.Analytical chemistry · 2022Article
- Article
- Digital Electrochemistry for On-Chip Heterogeneous Material Integration.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- On-Chip Cyclic Voltammetry Measurements Using a Compact 1024-Electrode CMOS IC.Analytical chemistry · 2021Article
- Quantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal-oxide-semiconductor electrode array.Nature communications · 2021Article
- Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes.iScience · 2019Review
- Drug testing complementary metal-oxide-semiconductor chip reveals drug modulation of transmitter release for potential therapeutic applications.Journal of neurochemistry · 2019Article
- Single-Cell Recording of Vesicle Release From Human Neuroblastoma Cells Using 1024-ch Monolithic CMOS Bioelectronics.IEEE transactions on biomedical circuits and systems · 2018Article
- A Bidirectional-Current CMOS Potentiostat for Fast-Scan Cyclic Voltammetry Detector Arrays.IEEE transactions on biomedical circuits and systems · 2018Article
- High-Density Redox Amplified Coulostatic Discharge-Based Biosensor Array.IEEE journal of solid-state circuits · 2018Article
- Electrochemical measurement of quantal exocytosis using microchips.Pflugers Archiv : European journal of physiology · 2018Review
- Surface-modified CMOS IC electrochemical sensor array targeting single chromaffin cells for highly parallel amperometry measurements.Pflugers Archiv : European journal of physiology · 2018Review
- Neurochemostat: A Neural Interface SoC With Integrated Chemometrics for Closed-Loop Regulation of Brain Dopamine.IEEE transactions on biomedical circuits and systems · 2016Article
- Electrochemical camera chip for simultaneous imaging of multiple metabolites in biofilms.Nature communications · 2016Article
- Non-Faradaic Electrochemical Detection of Exocytosis from Mast and Chromaffin Cells Using Floating-Gate MOS Transistors.Scientific reports · 2015Article
- Microelectronics-based biosensors dedicated to the detection of neurotransmitters: a review.Sensors (Basel, Switzerland) · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Neurotransmitter release is modulated by many drugs and molecular manipulations. We present an active CMOS-based electrochemical biosensor array with high throughput capability (100 electrodes) for on-chip amperometric measurement of neurotransmitter release. The high-throughput of the biosensor array will accelerate the data collection needed to determine statistical significance of changes produced under varying conditions, from several weeks to a few hours. The biosensor is designed and fabricated using a combination of CMOS integrated circuit (IC) technology and a photolithography process to incorporate platinum working electrodes on-chip. We demonstrate the operation of an electrode array with integrated high-gain potentiostats and output time-division multiplexing with minimum dead time for readout. The on-chip working electrodes are patterned by conformal deposition of Pt and lift-off photolithography. The conformal deposition method protects the underlying electronic circuits from contact with the electrolyte that covers the electrode array during measurement. The biosensor was validated by simultaneous measurement of amperometric currents from 100 electrodes in response to dopamine injection, which revealed the time course of dopamine diffusion along the surface of the biosensor array. The biosensor simultaneously recorded neurotransmitter release successfully from multiple individual living chromaffin cells. The biosensor was capable of resolving small and fast amperometric spikes reporting release from individual vesicle secretions. We anticipate that this device will accelerate the characterization of the modulation of neurotransmitter secretion from neuronal and endocrine cells by pharmacological and molecular manipulations of the cells.
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Registered trials
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