ArticleCell reports2012
An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- High-Throughput Quantification of miRNA-3'-Untranslated-Region Regulatory Effects.bioRxiv : the preprint server for biology · 2024Article
- Article
- Article
- Analysis of a miR-148a Targetome in B Cell Central Tolerance.Frontiers in immunology · 2022Article
- Circulatory miR-155 correlation with platelet and neutrophil recovery after autologous hematopoietic stem cell transplantation, a multivariate analysis.International journal of hematology · 2021Article
- 5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING.The EMBO journal · 2021Article
- Review
- Article
- Syngeneic red blood cell-induced extracellular vesicles suppress delayed-type hypersensitivity to self-antigens in mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- Biomarker Potential of Plasma MicroRNA-150-5p in Prostate Cancer.Medicina (Kaunas, Lithuania) · 2019Article
- MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression.EBioMedicine · 2019Article
- A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset.Nature communications · 2018Article
- miR-150 enhances apoptotic and anti-tumor effects of paclitaxel in paclitaxel-resistant ovarian cancer cells by targeting Notch3.Oncotarget · 2017Article
- Article
- Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation.Genome research · 2017Article
- MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis.Current stem cell reports · 2016Article
- Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer.Radiation oncology (London, England) · 2016Article
- The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.Nature immunology · 2016Article
- MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway.Immunology letters · 2016Article
- A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions.Nature communications · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Hematopoietic stem and progenitor cells are often undesired targets of chemotherapies, leading to hematopoietic suppression requiring careful clinical management. Whether microRNAs control hematopoietic injury response is largely unknown. We report an in vivo gain-of-function screen and the identification of miR-150 as an inhibitor of hematopoietic recovery upon 5-fluorouracil-induced injury. Utilizing a bone marrow transplant model with a barcoded microRNA library, we screened for barcode abundance in peripheral blood of recipient mice before and after 5-fluorouracil treatment. Overexpression of screen-candidate miR-150 resulted in significantly slowed recovery rates across major blood lineages, with associated impairment of bone marrow clonogenic potential. Conversely, platelets and myeloid cells from miR-150 null marrow recovered faster after 5-fluorouracil treatment. Heterozygous knockout of c-myb, a conserved target of miR-150, partially phenocopied miR-150-forced expression. Our data highlight the role of microRNAs in controlling hematopoietic injury response and demonstrate the power of in vivo functional screens for studying microRNAs in normal tissue physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.