Trial reportThe Journal of pediatrics2013
Effects of propranolol and exercise training in children with severe burns.
Trial report in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Systematic review of clinical outcome reporting in randomised controlled trials of burn care.BMJ open · 2019Pooled it
- Comparison of Six-Minute Walk Test and Modified Bruce Treadmill Test in Paediatric Patients With Severe Burns: A Cross-Over Study.Journal of rehabilitation medicine · 2022Trial
- One-Year Comparison of a Community-Based Exercise Program Versus a Day Hospital-Based Exercise Program on Quality of Life and Mental Health in Severely Burned Children.Archives of physical medicine and rehabilitation · 2020Trial
- Effects of Community-Based Exercise in Adults With Severe Burns: A Randomized Controlled Trial.Archives of physical medicine and rehabilitation · 2020Trial
- Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol.Annals of surgery · 2018Trial
- Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children.Medicine and science in sports and exercise · 2018Trial
- Effects of different duration exercise programs in children with severe burns.Burns : journal of the International Society for Burn Injuries · 2017Trial
- Effects of whole-body vibration exercise on bone mineral content and density in thermally injured children.Burns : journal of the International Society for Burn Injuries · 2016Trial
- Effects of community-based exercise in children with severe burns: A randomized trial.Burns : journal of the International Society for Burn Injuries · 2016Trial
- Early rehabilitative exercise training in the recovery from pediatric burn.Medicine and science in sports and exercise · 2014Trial
- Metabolic response to burn injury: a comprehensive bibliometric study.Frontiers in medicine · 2024Article
- [Research advances on the effect of resistance training on the rehabilitation of burned children].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Review
- Burn-induced hypermetabolism and skeletal muscle dysfunction.American journal of physiology. Cell physiology · 2021Review
- Glucose Metabolism in Burns-What Happens?International journal of molecular sciences · 2021Review
- Review
- Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.Burns : journal of the International Society for Burn Injuries · 2020Review
- Relationship between lean body mass and isokinetic peak torque of knee extensors and flexors in severely burned children.Burns : journal of the International Society for Burn Injuries · 2019Article
- The Long-Term Impact of Severe Burn Trauma on Musculoskeletal Health.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- Burn Injury May Have Age-Dependent Effects on Strength and Aerobic Exercise Capacity in Males.Journal of burn care & research : official publication of the American Burn Association · 2018Article
- Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training.Burns : journal of the International Society for Burn Injuries · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo investigate whether propranolol administration blocks the benefits induced by exercise training in severely burned children. STUDY
designChildren aged 7-18 years (n = 58) with burns covering ≥30% of the total body surface area were enrolled in this randomized trial during their acute hospital admission. Twenty-seven patients were randomized to receive propranolol, whereas 31 served as untreated controls. Both groups participated in 12 weeks of in-hospital resistance and aerobic exercise training. Muscle strength, lean body mass, and peak oxygen consumption (VO2 peak) were measured before and after exercise training. Paired and unpaired Student t tests were used for within and between group comparisons, and χ(2) tests for nominal data.
resultsAge, length of hospitalization, and total body surface area burned were similar between groups. In both groups, muscle strength, lean body mass, and VO2 peak were significantly greater after exercise training than at baseline. The percent change in VO2 peak was significantly greater in the propranolol group than in the control group (P < .05).
conclusionsExercise-induced enhancements in muscle mass, strength, and VO2 peak are not impaired by propranolol. Moreover, propranolol improves the aerobic response to exercise in massively burned children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.