ArticleSchizophrenia research2012
Dedifferentiation and substitute strategy: deconstructing the processing-speed impairment in schizophrenia.
Article in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- The latent structure of working memory: A large sample factor model of working memory capacity.Cognitive, affective & behavioral neuroscience · 2025Article
- Greater Fatigue and Reduced Neurocognitive Speed With Symptomatic Crohn's Disease.Crohn's & colitis 360 · 2025Article
- Construction of a computerized adaptive test (CAT-CCNB) for efficient neurocognitive and clinical psychopathology assessment.Journal of neuroscience methods · 2023Article
- Generalized neurocognitive impairment in individuals at ultra-high risk for psychosis: The possible key role of slowed processing speed.Brain and behavior · 2021Article
- A QTL on chromosome 3q23 influences processing speed in humans.Genes, brain, and behavior · 2019Article
- Clinical correlates of subsyndromal depression in African American individuals with psychosis: The relationship with positive symptoms and comorbid substance dependence.Schizophrenia research · 2019Article
- Longitudinal Cognitive Changes in Young Individuals at Ultrahigh Risk for Psychosis.JAMA psychiatry · 2018Article
- The Processing-Speed Impairment in Psychosis Is More Than Just Accelerated Aging.Schizophrenia bulletin · 2017Article
- Compromised Motor Dexterity Confounds Processing Speed Task Outcomes in Stroke Patients.Frontiers in neurology · 2017Article
- Diagnosis and neurocognitive profiles in first-episode non-affective psychosis patients.European archives of psychiatry and clinical neuroscience · 2016Article
- Frontal Glutamate and γ-Aminobutyric Acid Levels and Their Associations With Mismatch Negativity and Digit Sequencing Task Performance in Schizophrenia.JAMA psychiatry · 2016Article
- Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study.Molecular psychiatry · 2016Article
- The puzzle of processing speed, memory, and executive function impairments in schizophrenia: fitting the pieces together.Biological psychiatry · 2015Article
- Response selection impairment in schizophrenia transcends sensory and motor modalities.Schizophrenia research · 2014Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundRecent research has identified impairment in processing speed, measured by the digit-symbol substitution task, as central to the cognitive deficit in schizophrenia. However, the underlying cognitive correlates of this impairment remain unknown.
methodsA sample of cases (N=125) meeting DSM-IV criteria for schizophrenia and a sample of community controls (N=272) from the same geographical area completed a set of putative measures of processing-speed ability to which we implemented confirmatory factor and structural regression modelling in order to elucidate the latent structure of processing speed. Next, we tested the degree to which the structural and relational portions of the model were equal across groups.
resultsProcessing-speed ability was best defined, in both controls and cases (χ(2)=38.59(26), p=0.053), as a multidimensional cognitive ability consisting of three latent factors comprising: psychomotor speed, sequencing and shifting, and verbal fluency. However, cases exhibited dedifferentiation (i.e., markedly stronger inter-correlations between factors; χ(2)=59.94(29), p<.01) and a reliance on an alternative ensemble of cognitive operations to controls when completing the digit-symbol substitution task.
conclusionDedifferentiation of processing-speed ability in schizophrenia and subsequent overreliance on alternative (and possibly less than optimal) cognitive operations underlies the marked deficit observed on the digit-symbol substitution task.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.