ArticleDrug and alcohol dependence2013
Decreased frontal lobe phosphocreatine levels in methamphetamine users.
Article in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- The role of brain creatine in behavioral health conditions.Frontiers in psychiatry · 2025Review
- Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts.Neuroscience and biobehavioral reviews · 2022Review
- Metabolite Alternations in the Dopamine Circuit Associated with Methamphetamine-Related Psychotic Symptoms: A Proton Magnetic Resonance Spectroscopy Study.Iranian journal of psychiatry · 2022Article
- Magnetic resonance spectroscopy studies of substance use disorders: Current landscape and potential future directions.Pharmacology, biochemistry, and behavior · 2021Review
- CNS metabolism in high-risk drug abuse : Insights gained fromDer Radiologe · 2018Review
- Psychostimulant drug effects on glutamate, Glx, and creatine in the anterior cingulate cortex and subjective response in healthy humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users.Addiction biology · 2018Article
- The neurochemical consequences of methamphetamine self-administration in male and female rats.Drug and alcohol dependence · 2017Article
- [CNS metabolism in high-risk drug abuse, German version : Insights gained fromDer Radiologe · 2017Review
- Mitochondrial injury and cognitive function in HIV infection and methamphetamine use.AIDS (London, England) · 2016Article
- Decreased brain PME/PDE ratio in bipolar disorder: a preliminary (31) P magnetic resonance spectroscopy study.Bipolar disorders · 2015Article
- Hippocampal volume reduction in female but not male recent abstinent methamphetamine users.Behavioural brain research · 2015Article
- Interaction of methamphetamine abuse, tobacco abuse, and gender in the brain.The American journal of drug and alcohol abuse · 2015Article
- Gender differences in the effect of tobacco use on brain phosphocreatine levels in methamphetamine-dependent subjects.The American journal of drug and alcohol abuse · 2015Article
- Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: a population-based assessment.Drug and alcohol dependence · 2015Article
- Brain metabolite changes in subcortical regions after exposure to cuprizone for 6 weeks: potential implications for schizophrenia.Neurochemical research · 2015Article
- Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study.Journal of dual diagnosis · 2015Article
- Methamphetamine affects cell proliferation in the medial prefrontal cortex: a new niche for toxicity.Pharmacology, biochemistry, and behavior · 2014Article
- Neuroimaging in Alcohol and Drug Dependence.Current behavioral neuroscience reports · 2014Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMitochondria-related mechanisms have been suggested to mediate methamphetamine (METH) toxicity. However, changes in brain energetics associated with high-energy phosphate metabolism have not been investigated in METH users. Phosphorus-31 ((31)P) magnetic resonance spectroscopy (MRS) was used to evaluate changes in mitochondrial high energy phosphates, including phosphocreatine (PCr) and β-nucleoside triphosphate (β-NTP, primarily ATP in brain) levels. We hypothesized that METH users would have decreased high-energy PCr levels in the frontal gray matter.
methodsStudy participants consisted of 51 METH (age=32.8±6.7) and 23 healthy comparison (age=31.1±7.5) subjects. High-energy phosphate metabolite levels were compared between the groups and potential gender differences were explored.
resultsMETH users had lower ratios of PCr to total pool of exchangeable phosphate (PCr/TPP) in the frontal lobe as compared to the healthy subjects (p=.001). The lower PCr levels in METH subjects were significantly associated with lifetime amount of METH use (p=.003). A sub-analysis for gender differences revealed that female METH users, who had lower daily amounts (1.1±1.0g) of METH use than males (1.4±1.7g), had significantly lower PCr/TPP ratios than male METH users, controlling for the amount of METH use (p=.02).
conclusionsThe present findings suggest that METH compromises frontal lobe high-energy phosphate metabolism in a dose-responsive manner. Our findings also suggest that the abnormality in frontal lobe high-energy phosphate metabolism might be more prominent in female than in male METH users. This is significant as decreased PCr levels have been associated with depressive symptoms, and poor responses to antidepressant treatment have been reported in those with decreased PCr levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.