Evidence map›Paper›PMID 23084398›Full record

ReviewTrends in biochemical sciences2012

Interplay of DNA repair with transcription: from structures to mechanisms.

Alexandra M Deaconescu, Irina Artsimovitch, Nikolaus Grigorieff

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Regulation of Transcript Elongation.Annual review of microbiology · 2015
    Review
  10. Article
  11. Stalled transcription complexes promote DNA repair at a distance.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  12. Article
  13. RNA polymerase between lesion bypass and DNA repair.Cellular and molecular life sciences : CMLS · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexandra M DeaconescuHoward Hughes Medical Institute, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South St., MS 029, Waltham, MA 02454, USA. deacona@brandeis.edu
Irina Artsimovitch
Nikolaus Grigorieff
Brandeis University · USThe Ohio State University · US

Funding

Single particle reconstructionP01GM062580 · NIGMS · HARVARD MEDICAL SCHOOL · PI LI, ZONGLI · 2001 to 2016
$23.7M
Mechnanism of transcript elongation control by RfaHR01GM067153 · NIGMS · OHIO STATE UNIVERSITY · PI IRINA ARTSIMOVITCH · 2003 to 2026
$8.0M
Howard Hughes Medical InstituteNIGMS NIH HHS P01 GM062580NIGMS NIH HHS R01 GM067153
6 · The paper itself

Abstract

Many DNA transactions are crucial for maintaining genomic integrity and faithful transfer of genetic information but remain poorly understood. An example is the interplay between nucleotide excision repair (NER) and transcription, also known as transcription-coupled DNA repair (TCR). Discovered decades ago, the mechanisms for TCR have remained elusive, not in small part due to the scarcity of structural studies of key players. Here we summarize recent structural information on NER/TCR factors, focusing on bacterial systems, and integrate it with existing genetic, biochemical, and biophysical data to delineate the mechanisms at play. We also review emerging, alternative modalities for recruitment of NER proteins to DNA lesions.

Indexed as

AnimalsDNADNA-Binding ProteinsDNA DamageDNA RepairHumansProtein ConformationTranscription FactorsTranscription, GeneticDNADNA-Binding ProteinsTranscription Factors

Identifiers

PMID23084398
PMCPMC3588851
OpenAlexW1993272538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.