Evidence map›Paper›PMID 23084143›Full record

ReviewThe ocular surface2012

Wakayama Symposium: Notch-FoxL2-α-SMA axis in eyelid levator muscle development and congenital blepharophimosis.

Chia-Yang Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The ocular surface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Novel Genetic Variants of Sporadic Atrial Septal Defect (ASD) in a Chinese Population Identified by Whole-Exome Sequencing (WES).Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Chia-Yang LiuEdith J. Crawley Vision Research Center/Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA. Electronic address: Liucg@uc.edu.
University of Cincinnati · US

Funding

THE ROLE OF KERATOCAN IN CORNEAL BIOLOGYR01EY012486 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIU, CHIA-YANG · 2001 to 2010
$2.1M
Mouse Model for Eyelid Disease: Congenital BlepharophimosisR01EY021501 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2011 to 2015
$1.9M
NEI NIH HHS EY21501NEI NIH HHS R01 EY012486NEI NIH HHS R01 EY021501NEI NIH HHS R01 EY12486
6 · The paper itself

Abstract

This review summarizes our recent findings regarding the Notch signaling pathway in regulating normal eyelid morphogenesis and its role in the pathogenesis of human congenital blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). We used genetic and molecular biological approaches to investigate the mechanism by which Notch1 activation controls expression of FoxL2, which in turn activates smooth muscle actin gene expression in periocular mesenchyma to control eyelid levator smooth muscle formation.

Indexed as

ActinsBlepharophimosisEyelidsForkhead Box Protein L2Forkhead Transcription FactorsHumansMuscle, SkeletalReceptor, Notch1ActinsForkhead Box Protein L2Forkhead Transcription FactorsFOXL2 protein, humanNOTCH1 protein, humanReceptor, Notch1

Identifiers

PMID23084143
PMCPMC3495103
OpenAlexW2070590758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.