ArticleNeuron2012
Imaging neural activity using Thy1-GCaMP transgenic mice.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
What it found
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Who cites it
137 citing papers in PubMed, 223 citations in OpenAlex.
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- Transcranial Calcium Macro-Imaging From the Auditory Cortex of Thy1-Cre-Driven GCaMP8 Transgenic Rats.Neuropsychopharmacology reports · 2026Article
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- Monitoring presynaptic calcium dynamics with membrane-impermeant fluorescent indicators in motor nerve endings.Biophysical reviews · 2025Review
- Characterization of iGABASnFR2 forNeurophotonics · 2025Article
- Advances in two-photon imaging for monitoring neural activity in behaving mice.Frontiers in neuroscience · 2025Review
- Longitudinal changes in electrophysiology and widefield calcium imaging following electrode implantation.Journal of neural engineering · 2024Article
- Volumetric voltage imaging of neuronal populations in the mouse brain by confocal light-field microscopy.Nature methods · 2024Article
- Brief and Diverse Excitotoxic Insults Increase the Neuronal Nuclear Membrane Permeability in the Neonatal Brain, Resulting in Neuronal Dysfunction and Cell Death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging - A Symposium Review.Neuroinformatics · 2024Review
- Integrated Microprism and Microelectrode Array for Simultaneous Electrophysiology and Two-Photon Imaging across All Cortical Layers.Advanced healthcare materials · 2024Article
- Trauma in Neonatal Acute Brain Slices Alters Calcium and Network Dynamics and Causes Calpain-Mediated Cell Death.eNeuro · 2024Article
- Protocol for calcium imaging and analysis of hippocampal CA1 activity evoked by non-spatial stimuli.STAR protocols · 2024Article
- A Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics.Scientific reports · 2024Article
- A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics.bioRxiv : the preprint server for biology · 2023Article
- Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
The ability to chronically monitor neuronal activity in the living brain is essential for understanding the organization and function of the nervous system. The genetically encoded green fluorescent protein-based calcium sensor GCaMP provides a powerful tool for detecting calcium transients in neuronal somata, processes, and synapses that are triggered by neuronal activities. Here we report the generation and characterization of transgenic mice that express improved GCaMPs in various neuronal subpopulations under the control of the Thy1 promoter. In vitro and in vivo studies show that calcium transients induced by spontaneous and stimulus-evoked neuronal activities can be readily detected at the level of individual cells and synapses in acute brain slices, as well as chronically in awake, behaving animals. These GCaMP transgenic mice allow investigation of activity patterns in defined neuronal populations in the living brain and will greatly facilitate dissecting complex structural and functional relationships of neural networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.