ArticleActa orthopaedica2012
Increasing risk of prosthetic joint infection after total hip arthroplasty.
Article in Acta orthopaedica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 134 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Periprosthetic Joint Infection and Debridement, Antibiotics and Implant Retention in Arthroplasty for Femoral Neck Fracture
Assessment and Treatment Responses to Patient Education and Basic Body Awareness Therapy in Hip Osteoarthritis: a Randomized Controlled Trial
REVISITS Trial: Revision Single or Two Stage Surgery for Periprosthetic Hip Infection - a Multicentre Randomized Clinical Trial
Airflow and Hip Prosthesis Infections: A Registry Study Comparing Laminar vs. Turbulent Flow in the Danish Hip Arthroplasty Register.
Who cites it
134 citing papers in PubMed, 10 syntheses or guidelines pooled it, 277 citations in OpenAlex.
- Risk factors for metachronous periprosthetic joint infection in patients with multiple prosthetic joints: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Incidence of periprosthetic joint infection after primary total hip arthroplasty is underestimated: a synthesis of meta-analysis and bibliometric analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Dual-mobility cups could yield lesser infections than conventional cups: a meta-analysis of comparative studies.International orthopaedics · 2021Pooled it
- D-dimer in the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2019Pooled it
- Antibiotic prophylaxis is not indicated prior to dental procedures for prevention of periprosthetic joint infections.Acta orthopaedica · 2017Guideline
- The Alpha-Defensin Immunoassay and Leukocyte Esterase Colorimetric Strip Test for the Diagnosis of Periprosthetic Infection: A Systematic Review and Meta-Analysis.The Journal of bone and joint surgery. American volume · 2016Pooled it
- Patient, Surgery, and Hospital Related Risk Factors for Surgical Site Infections following Total Hip Arthroplasty.TheScientificWorldJournal · 2015Pooled it
- Re-Infection Outcomes following One- and Two-Stage Surgical Revision of Infected Hip Prosthesis: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Single- or two-stage revision for infected total hip arthroplasty? A systematic review of the literature.Clinical orthopaedics and related research · 2014Pooled it
- Trial
- Rifampin combination therapy in staphylococcal prosthetic joint infections: a randomized controlled trial.Journal of orthopaedic surgery and research · 2020Trial
- Iatrogenic Hypercalcaemia Secondary to Antibiotic-Eluting Absorbable Calcium-Sulphate Beads in Orthopaedic Surgery.Cureus · 2025Article
- Two-stage exchange of infected total hip arthroplasty with a dual-mobility cup is associated with a low instability rate.SICOT-J · 2025Article
- Mid-term to long-term outcome and risk factors for failure of 158 hips with two-stage revision for periprosthetic hip joint infection.Journal of bone and joint infection · 2025Article
- Concerns with alumina bipolar hemiarthroplasties compared to metal bipolar hemiarthroplasties when performed for nontraumatic osteonecrosis of the femoral head.International orthopaedics · 2024Article
- Analysis of the airflow features and ventilation efficiency of an Ultra-Clean-Air operating theatre by qDNS simulations and experimental validation.Building and environment · 2024Article
- Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement.JAMA network open · 2024Article
- Article
- Investigating the in vitro antibacterial efficacy of composite bone cement incorporating natural product-based monomers and gentamicin.Journal of orthopaedic surgery and research · 2024Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe risk of revision due to infection after primary total hip arthroplasty (THA) has been reported to be increasing in Norway. We investigated whether this increase is a common feature in the Nordic countries (Denmark, Finland, Norway, and Sweden). MATERIALS AND
methodsThe study was based on the Nordic Arthroplasty Register Association (NARA) dataset. 432,168 primary THAs from 1995 to 2009 were included (Denmark: 83,853, Finland 78,106, Norway 88,455, and Sweden 181,754). Adjusted survival analyses were performed using Cox regression models with revision due to infection as the endpoint. The effect of risk factors such as the year of surgery, age, sex, diagnosis, type of prosthesis, and fixation were assessed.
results2,778 (0.6%) of the primary THAs were revised due to infection. Compared to the period 1995-1999, the relative risk (with 95% CI) of revision due to infection was 1.1 (1.0-1.2) in 2000-2004 and 1.6 (1.4-1.7) in 2005-2009. Adjusted cumulative 5-year revision rates due to infection were 0.46% (0.42-0.50) in 1995-1999, 0.54% (0.50-0.58) in 2000-2004, and 0.71% (0.66-0.76) in 2005-2009. The entire increase in risk of revision due to infection was within 1 year of primary surgery, and most notably in the first 3 months. The risk of revision due to infection increased in all 4 countries. Risk factors for revision due to infection were male sex, hybrid fixation, cement without antibiotics, and THA performed due to inflammatory disease, hip fracture, or femoral head necrosis. None of these risk factors increased in incidence during the study period.
interpretationWe found increased relative risk of revision and increased cumulative 5-year revision rates due to infection after primary THA during the period 1995-2009. No change in risk factors in the NARA dataset could explain this increase. We believe that there has been an actual increase in the incidence of prosthetic joint infections after THA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.