ArticleBMC evolutionary biology2012
Balancing selection and genetic drift at major histocompatibility complex class II genes in isolated populations of golden snub-nosed monkey (Rhinopithecus roxellana).
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- MHC class II genes influence the gut microbiota of wild golden snub-nosed monkeys.BMC microbiology · 2026Article
- Multi-omic profiling reveals distinct gut microbial and metabolic landscapes in golden snub-nosed monkeys under contrasting conservation strategies.NPJ biofilms and microbiomes · 2025Article
- Balancing selection shapes population differentiation of major histocompatibility complex genes in wild golden snub-nosed monkeys.Current zoology · 2024Article
- Moderate Genetic Diversity of MHC Genes in an Isolated Small Population of Black-and-White Snub-Nosed Monkeys (Animals : an open access journal from MDPI · 2024Article
- Review
- Complex patterns shape immune genes diversity during invasion of common raccoon in Europe - Selection in action despite genetic drift.Evolutionary applications · 2023Article
- Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution.BMC evolutionary biology · 2020Article
- MHC-Based Mate Choice in Wild Golden Snub-Nosed Monkeys.Frontiers in genetics · 2020Article
- Article
- Home range variation of two different-sized groups of golden snub-nosed monkeys (Zoological research · 2019Article
- Identifying refugia and corridors under climate change conditions for the Sichuan snub-nosed monkey (Ecology and evolution · 2019Article
- Small-scale intraspecific patterns of adaptive immunogenetic polymorphisms and neutral variation in Lake Superior lake trout.Immunogenetics · 2018Article
- Genetic wealth, population health: Major histocompatibility complex variation in captive and wild ring-tailed lemurs (Ecology and evolution · 2017Article
- Spatial patterns of immunogenetic and neutral variation underscore the conservation value of small, isolated American badger populations.Evolutionary applications · 2016Article
- The influence of positive selection and trans-species evolution on DPB diversity in the golden snub-nosed monkeys (Rhinopithecus roxellana).Primates; journal of primatology · 2016Article
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
- Genetic diversity and differentiation of the rhesus macaque (Macaca mulatta) population in western Sichuan, China, based on the second exon of the major histocompatibility complex class II DQB (MhcMamu-DQB1) alleles.BMC evolutionary biology · 2014Article
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4 authors at 3 institutions in 1 country.
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Abstract
backgroundSmall, isolated populations often experience loss of genetic variation due to random genetic drift. Unlike neutral or nearly neutral markers (such as mitochondrial genes or microsatellites), major histocompatibility complex (MHC) genes in these populations may retain high levels of polymorphism due to balancing selection. The relative roles of balancing selection and genetic drift in either small isolated or bottlenecked populations remain controversial. In this study, we examined the mechanisms maintaining polymorphisms of MHC genes in small isolated populations of the endangered golden snub-nosed monkey (Rhinopithecus roxellana) by comparing genetic variation found in MHC and microsatellite loci. There are few studies of this kind conducted on highly endangered primate species.
resultsTwo MHC genes were sequenced and sixteen microsatellite loci were genotyped from samples representing three isolated populations. We isolated nine DQA1 alleles and sixteen DQB1 alleles and validated expression of the alleles. Lowest genetic variation for both MHC and microsatellites was found in the Shennongjia (SNJ) population. Historical balancing selection was revealed at both the DQA1 and DQB1 loci, as revealed by excess non-synonymous substitutions at antigen binding sites (ABS) and maximum-likelihood-based random-site models. Patterns of microsatellite variation revealed population structure. FST outlier analysis showed that population differentiation at the two MHC loci was similar to the microsatellite loci.
conclusionsMHC genes and microsatellite loci showed the same allelic richness pattern with the lowest genetic variation occurring in SNJ, suggesting that genetic drift played a prominent role in these isolated populations. As MHC genes are subject to selective pressures, the maintenance of genetic variation is of particular interest in small, long-isolated populations. The results of this study may contribute to captive breeding and translocation programs for endangered species.
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