ArticleInternational journal of radiation biology2013
Inhibition of radiation-induced skin fibrosis with imatinib.
Article in International journal of radiation biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Radiation-Induced Fibrosis (RIF) in Head and Neck Squamous Cell Carcinoma (HNSCC): A Review.Cells · 2025Review
- Radiation-Induced Fibrosis in Head and Neck Cancer: Challenges and Future Therapeutic Strategies for Vocal Fold Treatments.Cancers · 2025Review
- Tissue expansion mitigates radiation-induced skin fibrosis in a porcine model.Acta biomaterialia · 2024Article
- Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances.Journal of translational medicine · 2023Review
- 2-Methoxyestradiol Inhibits Radiation-Induced Skin Injuries.International journal of molecular sciences · 2022Article
- Cutaneous Radiation Injuries: Models, Assessment and Treatments.Radiation research · 2020Article
- C1222C Deletion in Exon 8 ofFrontiers in oncology · 2020Article
- Mast Cells in Skin Scarring: A Review of Animal and Human Research.Frontiers in immunology · 2020Article
- Acute Skin Damage and Late Radiation-Induced Fibrosis and Inflammation in Murine Ears after High-Dose Irradiation.Cancers · 2019Article
- Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer.Radiation oncology (London, England) · 2018Article
- Imatinib mesylate use in refractory eosinophilic granulomatosis with polyangiitis: a literature review and a case report.Clinical rheumatology · 2018Review
- Article
- Radiation-induced fibrosis: mechanisms and implications for therapy.Journal of cancer research and clinical oncology · 2015Review
- Studies in fat grafting: Part III. Fat grafting irradiated tissue--improved skin quality and decreased fat graft retention.Plastic and reconstructive surgery · 2014Article
- Management of fibrosis: the mesenchymal stromal cells breakthrough.Stem cells international · 2014Review
- Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation.Stem cells (Dayton, Ohio) · 2013Article
- Radiation Fibrosis Syndrome: the Evergreen Menace of Radiation Therapy.Asia-Pacific journal of oncology nursingReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeDermal fibrosis is a disabling late toxicity of radiotherapy. Several lines of evidence suggest that overactive signaling via the Platelet-derived growth factor receptor-beta (PDGFR-β) and V-abl Abelson murine leukemia viral oncogene homolog 1 (cAbl) may be etiologic factors in the development of radiation-induced fibrosis. We tested the hypothesis that imatinib, a clinically available inhibitor of PDGFR-β, Mast/stem cell growth factor receptor (c-kit) and cAbl, would reduce the severity of dermal fibrosis in a murine model. MATERIALS AND
methodsThe right hind legs of female C3H/HeN mice were exposed to 35 Gy of X-rays. Cohorts of mice were maintained on chow formulated with imatinib 0.5 mg/g or control chow for the duration of the experiment. Bilateral hind limb extension was measured serially to assess fibrotic contracture. Immunohistochemistry and biochemical assays were used to evaluate the levels of collagen and cytokines implicated in radiation-induced fibrosis.
resultsImatinib treatment significantly reduced hind limb contracture and dermal thickness after irradiation. Immunohistochemical studies demonstrated a substantial reduction in PDGFR-β phosphorylation. We also observed reduced Transforming Growth factor-β (TGF-β) and collagen expression in irradiated skin of imatinib-treated mice, suggesting that imatinib may suppress the fibrotic process by interrupting cross-talk between these pathways.
conclusionsTaken together, these results support that imatinib may be a useful agent in the prevention and treatment of radiation-induced dermal fibrosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.