ArticleTissue engineering. Part A2013
Calcium-alginate hydrogel-encapsulated fibroblasts provide sustained release of vascular endothelial growth factor.
Article in Tissue engineering. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Calcium ions released from alginate hydrogel promote wound healing by enhancing fibroblast activity.Frontiers in bioengineering and biotechnology · 2026Article
- Development and Characterization of Hollow-Shell Collagen Microcapsules for Three-Dimensional Cell Culture.Gels (Basel, Switzerland) · 2025Article
- A Pill That Prints-An Ingestible Bioprinter for Non-Invasive Structured Bioink Deposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genetic and bioactive functionalization of bioinks for 3D bioprinting.Bioprocess and biosystems engineering · 2025Review
- Mesenchymal Stem Cells Loaded in Injectable Alginate Hydrogels Promote Liver Growth and Attenuate Liver Fibrosis in Cirrhotic Rats.Gels (Basel, Switzerland) · 2025Article
- The Utilisation of Hydrogels for iPSC-Cardiomyocyte Research.International journal of molecular sciences · 2023Review
- Microfluidic Seeding of Cells on the Inner Surface of Alginate Hollow Microfibers.Advanced healthcare materials · 2022Article
- MicroRNA-494 Inhibits the LRG1 Expression to Induce Proliferation and Migration of VECs in Rats following Myocardial Infarction.Molecular therapy. Nucleic acids · 2019Article
- 3D Printed porous polyamide macrocapsule combined with alginate microcapsules for safer cell-based therapies.Scientific reports · 2018Article
- 3D Printability of Alginate-Carboxymethyl Cellulose Hydrogel.Materials (Basel, Switzerland) · 2018Article
- Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D microenvironment.Scientific reports · 2016Article
- In vitro study of partially hydrolyzed poly(2-ethyl-2-oxazolines) as materials for biomedical applications.Journal of materials science. Materials in medicine · 2015Article
- A bio-hybrid tactile sensor incorporating living artificial skin and an impedance sensing array.Sensors (Basel, Switzerland) · 2014Article
- 3D printing facilitated scaffold-free tissue unit fabrication.Biofabrication · 2014Article
- PEG-maleimide hydrogels for protein and cell delivery in regenerative medicine.Annals of biomedical engineering · 2014Article
- Single-step laser-based fabrication and patterning of cell-encapsulated alginate microbeads.Biofabrication · 2013Article
- Alginate-based strategies for therapeutic vascularization.Therapeutic delivery · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vascularization of engineered or damaged tissues is essential to maintain cell viability and proper tissue function. Revascularization of the left ventricle (LV) of the heart after myocardial infarction is particularly important, since hypoxia can give rise to chronic heart failure due to inappropriate remodeling of the LV after death of cardiomyocytes (CMs). Fibroblasts can express vascular endothelial growth factor (VEGF), which plays a major role in angiogenesis and also acts as a chemoattractant and survival factor for CMs and cardiac progenitors. In this in vitro model study, mouse NIH 3T3 fibroblasts encapsulated in 2% w/v Ca-alginate were shown to remain viable for 150 days. Semiquantitative reverse transcription-polymerase chain reaction and immunohistochemistry demonstrated that over 21 days of encapsulation, fibroblasts continued to express VEGF, while enzyme-linked immunosorbent assay showed that there was sustained release of VEGF from the Ca-alginate during this period. The scaffold degraded gradually over the 21 days, without reduction in volume. Cells released from the Ca-alginate at 7 and 21 days as a result of scaffold degradation were shown to retain viability, to adhere to fibronectin in a normal manner, and continue to express VEGF, demonstrating their potential to further contribute to maintenance of cardiac function after scaffold degradation. This model in vitro study therefore demonstrates that fibroblasts encapsulated in Ca-alginate provide sustained release of VEGF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.